CREB-binding protein


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CREB-binding protein

[¦kreb ¦bin·diŋ ′prō‚tēn]
(cell and molecular biology)
A transcriptional coactivator that binds a phosphorylated domain of cyclic AMP-responsive element binding protein (CREB) to facilitate transcription initiation. Abbreviated CBP.
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Transgenic mice expressing a truncated form of CREB-binding protein (CBP) exhibit deficits in hippocampal synaptic plasticity and memory storage.
The researchers found that dietary restriction induces a transcription factor called CREB-binding protein (CBP), which controls the activity of genes that regulate cellular function.
The nuclear bodies contain, in addition to PML (in normal individuals), several important regulatory proteins including SUMO-1 (see next page), CREB-binding protein, retinoblastoma-susceptibility gene product (pRB), the death-domain-associated protein (Daxx), and p53.