CREB-binding protein


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CREB-binding protein

[¦kreb ¦bin·diŋ ′prō‚tēn]
(cell and molecular biology)
A transcriptional coactivator that binds a phosphorylated domain of cyclic AMP-responsive element binding protein (CREB) to facilitate transcription initiation. Abbreviated CBP.
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References in periodicals archive ?
Phosphorylated CREB (pCREB) then recruits another transcriptional co-factor called CREB-binding protein (CBP), which contains intrinsic HAT activity.
Partial depletion of CREB-binding protein reduces life expectancy in a mouse model of Huntington disease.
Targeting CREB-binding protein (CBP) loss of function as a therapeutic strategy in neurological disorders.