CBP

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Related to CREBBP: EP300

CBP

(cell and molecular biology)
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To evaluate the role of CREBBP on IFNT transcription, JEG-3 cells were cotransfected with the -654-IFNT-Luc construct along with Jun, Ets2, and/or Cdx2 expression plasmids, either with or without Oct4 or a CREBBP inhibitor, 12S E1A.
To determine whether either of these transcription factors directly interact with CREBBP, thereby resulting in changes in ovine IFNT gene transcription, co-immunoprecipitation studies were carried out.
Mocetinostat is being developed as a single agent treatment targeting mutations and deletions of the histone acetyltransferase (HAT) genes CREBBP and EP300.
The primary objective of the Phase 2 study is to determine the efficacy of mocetinostat in patients with previously treated, locally advanced, unresectable or metastatic urothelial carcinoma harboring inactivating mutations or deletions of the HAT genes CREBBP and/or EP300.
Working closely with our investigators and reviewing emerging cancer genomics research, we've identified CREBBP and EP300 as potential drivers of disease progression that may be particularly susceptible to treatment with mocetinostat.
Mirati is partnering with Foundation Medicine to use their comprehensive genomic profile to screen patients for genomic alterations of CREBBP and EP300 genes prior to clinical trial enrollment
Investigators say the gene is a potential indicator of relapse risk because of the high frequency of CREBBP mutations in relapsed patients and evidence the changes persisted from diagnosis or emerged at relapse from subpopulations of leukemia cells present from the beginning.