The researchers found that LukED latches onto surface receptors called CXCR1
and CXCR2, creating the same deadly pores that it does when it latches onto CCR5 receptors.
The biologic role of interIeukin-8: functional analysis and expression of CXCR1
and CXCR2 on human eosinophils.
Expression of the chemokine receptors CXCR1
and CXCR2 on granulocytes in human endotoxemia and tuberculosis: involvement of the p38 mitogen-activated protein kinase pathway.
Reparixin is an inhibitor of the CXCR1
receptor activated by chemokine interleukin 8.
Nonapical and cytoplasmic expression of interleukin, CXCR1
, and CXCR2 correlates with cell proliferation and microvessel density in prostate can cer.
They have identified a receptor called, CXCR1
, on the cancer stem cells, which triggers growth of stem cells in response to inflammation and tissue damage.
In contrast, resting T cells express more CXCR1
, 2, and 4.