calpain(redirected from Calpain-1)
Also found in: Dictionary, Medical.
(cell and molecular biology)
A calcium-dependent cysteine protease in the cytoplasm that is central to most processes in cell biology (plasma membrane-associated signaling events; cell proliferation, differentiation, activation, and communication; and programmed cell death). Its overactivation has been observed in muscular dystrophy, Alzheimer's disease, AIDS, cataract formation, multiple sclerosis, and arthritis.