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camptothecin

   Also found in: Wikipedia 0.01 sec.
camptothecin [‚kam·tō′thē·sən]
(pharmacology)
An alkaloid belonging to the family of drugs called topoisomerase inhibitors which is used as an anticancer drug, it is the first known naturally produced DNA topoisomerase inhibitor and was originally isolated from the Chinese treeCamptothecin acuminate.
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A Schizosaccharomyces pombe knockout mutant of Pnk1, the fission yeast ortholog of hPNK, exhibited hypersensitivity to ionizing radiation and camptothecin (a topoisomerase I inhibitor), both of which induce DNA strand breaks (11).
Stable Down-Regulation of Human Polynucleotide Kinase Enhances ... by Feridoun Karimi-Busheri / Biological sciences community
The chemical created so much excitement that the government turned over federal land in Chico to cultivate Camptotheca acuminata, the Chinese shrub from which camptothecin was derived.
Chemical engineer brings home the medicine by The Star (Amman, Jordan)
Remaining papers are presented under the heading "plants as drug factories" and include such topics as intellectual property protection of plant biotechnology, breeding of medicinal plants, camptothecin production in cell cultures of Ophiorrhiza, and biological production of artemisinin for malaria therapy.
Medicinal plant biotechnology; from basic research to industrial ... by SciTech Book News
 
 
 
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