Carbonic Anhydrase

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carbonic anhydrase

[kär′bän·ik an′hī‚drās]
(biochemistry)
An enzyme which aids carbon dioxide transport and release by catalyzing the synthesis, and the dehydration, of carbonic acid from, and to, carbon dioxide and water.

Carbonic Anhydrase

 

carboanhydrase, carbonate hydrolase, an enzyme of the lyase class that catalyzes the reversible formation of carbonic acid from carbon dioxide and water: CO2 + H 2O ⇄H2CO3.. Carbonicanhydrase is a metallo-protein containing zinc. Molecular weight, about 30, 000.

Carbonic anhydrase is found in erythrocytes and in cells of the kidneys, the gastric mucosa, and the retina of the eye. Erythrocytic carbonic anhydrase provides for the bonding of CO2with blood in the tissues and for its rapid release in the lungs or branchia. Carbonic anhydrase makes for the formation of acid urine in the kidney, hydrochloric acid in the gastric mucosa, bicarbonates of pancreatic juice in the pancreas, and eggshells (containing CaCO3) in the oviducts of birds. Carbonic anhydrase is specifically and strongly inhibited by sulfonamides, which contain an aromatic group. Diamox (acetazolamide), Pentazane (methazolamide), and other agents used in the treatment of glaucoma and diseases of the retina and nervous system are examples of especially active carbonic anhydrase inhibitors. Carbonic anhydrase also occurs in the leaves of certain plants.

E. IU. CHENYKAEVA

References in periodicals archive ?
Serum antibodies to carbonic anhydrase I and II in patients with idiopathic chronic pancreatitis and Sjogren's syndrome.
Carbonic anhydrase is essential for calcifying organisms because it catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons, and provides the bicarbonate necessary for calcium precipitation.
Using a method developed by the authors, they were able to identify active carbonic anhydrase in the narrower part of the gland and confirm that carbonic anhydrase is indeed responsible for generating the pH gradient.

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