Carboxyhemoglobin

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Related to Carboxyhaemoglobin: carbon monoxide poisoning, methemoglobin, carboxyhemoglobin test

carboxyhemoglobin

[kär¦bäk·sē¦hē·mə‚glō·bən]
(biochemistry)

Carboxyhemoglobin

 

HbCO, a compound formed by the binding of carbon monoxide (CO) to hemoglobin (Hb).

Carboxyhemoglobin solutions are bright red. Their absorption spectrum has maximums at wavelengths of 570 and 539 mμ. Carboxyhemoglobin breaks down to Hb and CO 10, 000 times more slowly than does oxyhemoglobin to Hb and O2. Therefore, when CO is present in inhaled air the oxygen is gradually displaced from the hemoglobin. Even at an atmospheric CO concentration of 0.1 percent, more than half the hemoglobin in the blood is converted to carboxyhemoglobin, interfering with the transfer of O2 from the lungs to the tissues and causing carbonmonoxide poisoning.

References in periodicals archive ?
Validity of CO-oximetric determination of carboxyhaemoglobin in putrefying blood and body cavity fluid.
1999) Smoking-induced elevations in blood carboxyhaemoglobin levels.
Further tests carried out on one blood sample, showed the presence of drugs such as Fluoxetine, known as Prozac and other related breakdown products, and Albendazole, an active ingredient in medication prescribed for the treatment of worms, as well as a high level of carboxyhaemoglobin, an indicator of a large amount of carbon monoxide in the blood.
This dose equivalence is consistent with the reported three to fivefold greater levels of carboxyhaemoglobin (a marker of carbon monoxide exposure) and tar inhaled when smoking a cannabis joint compared with a tobacco cigarette of the same size.
The high concentration of oxygen you breathe in helps the body make oxyhaemoglobin quickly and replace carboxyhaemoglobin.
Greater levels of carboxyhaemoglobin decrease choroidal blood flow.
It can combine with the hemoglobin in blood to form carboxyhaemoglobin, and can therefore be lethal with prolonged exposure by preventing the flow of oxygen through the bloodstream.
CO, a product of tobacco combustion, binds with haemoglobin (Hb) to form carboxyhaemoglobin (COHb) which deprives Hb of its oxygen-carrying capacity.