Carboxyhemoglobin


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carboxyhemoglobin

[kär¦bäk·sē¦hē·mə‚glō·bən]
(biochemistry)

Carboxyhemoglobin

 

HbCO, a compound formed by the binding of carbon monoxide (CO) to hemoglobin (Hb).

Carboxyhemoglobin solutions are bright red. Their absorption spectrum has maximums at wavelengths of 570 and 539 mμ. Carboxyhemoglobin breaks down to Hb and CO 10, 000 times more slowly than does oxyhemoglobin to Hb and O2. Therefore, when CO is present in inhaled air the oxygen is gradually displaced from the hemoglobin. Even at an atmospheric CO concentration of 0.1 percent, more than half the hemoglobin in the blood is converted to carboxyhemoglobin, interfering with the transfer of O2 from the lungs to the tissues and causing carbonmonoxide poisoning.

References in periodicals archive ?
It has been reported that visual disorder may occur when carboxyhemoglobin is 30-40% (14).
With a cutoff of 6% and higher for carboxyhemoglobin, the sensitivity was 46% and the specificity was 94% to detect a smoker, with a positive predictive value of 67% and a negative predictive value of 87%, said Dr.
Broder said he was struck by "how some people with CO poisoning were relatively asymptomatic" and how patients with similar carboxyhemoglobin levels "had such varying clinical presentations.
The most characteristic sign of CO poisoning is a cherry color of the skin and mucous membranes due to the bright red color of carboxyhemoglobin.
In 2005, Masimo introduced rainbow SET[R] Pulse CO-Oximetry[TM] technology, allowing noninvasive and continuous monitoring of blood constituents that previously required invasive procedures, including total hemoglobin (SpHb[R]), oxygen content (SpOC[TM]), carboxyhemoglobin (SpCO[R]), methemoglobin (SpMet[R]), and Pleth Variability Index (PVI[R]), in addition to SpO2, pulse rate, and perfusion index (PI).
In conjunction with the appropriate Philips patient monitoring platform, Masimos rainbow SET technology analyzes multiple wavelengths of light to accurately measure total hemoglobin (SpHb), oxygen content (SpOC), carboxyhemoglobin (SpCO), methemoglobin (SpMet) and Pleth Variability Index (PVI) non-invasively and continuously.
carboxyhemoglobin, exhaled CO, lymphocyte DNA damage, urinary 1-hydroxypyrene, or ST-segment depression) in the residents of the home (Eppler et al.
Once absorbed, the smoke creates methhemoglobin and carboxyhemoglobin in the patient's blood.
11 parameters include: 1) oxygen saturation (SpO2); 2) Pulse rate; 3) Perfusion index (PI); 4) Pleth Variability Index (PVI); 5) Respiration Rate from the pleth (RRp); 6) Total hemoglobin (SpHb); 7) Oxygen Content (SpOC); 8) Carboxyhemoglobin (SpCO); 9) Methemoglobin (SpMet); 10) Fractional oxygen saturation (SpfO2); 11) Oxygen Reserve Index (ORI)
In clinical chemistry, the hallmark of these protective systems is the unconjugated hyperbilirubinemia associated with hemolysis and even a mild/moderate increase of carboxyhemoglobin.