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Related to Carboxylation: hydroxylation


(organic chemistry)
Addition of a carboxyl group into a molecule.



the direct introduction of the carboxyl group —COOH to organic compounds by the action of CO2. For example, carboxylation of organometallic compounds occurs during the passage of CO2 through a solution of the compound; subsequent hydrolysis yields carboxylic acid:

Salicylic acid and ^-aminosalicylic acid (PASA), used in medicine, are obtained through a singular carboxylation process involving the corresponding phenolates, for example

Carboxylation in an organism is effected by specific enzymes, forexample, pyruvate carboxylase catalyzes the carboxylation ofpyruvic acid. Carboxylation plays an important role in the oxida-tion of intermediate products of the decomposition of carbohy-drates, fats, and proteins in the organism.

References in periodicals archive ?
We conclude that the second carboxylation will be located at the TMCP ring since there were no fragments at m/z 97 or m/z 125.
The Effect of Menaquinone-7 (Vitamin K2) Supplementation on Osteocalcin Carboxylation in Healthy Prepubertal Children," Br.
Directions: Carbon Fixation = Carboxylation step; Rubisco (the minister) joins the two together to form a 6-carbon compound.
2], which is the only substrate for the RuBisCO catalyzed carboxylation reaction.
In the diagram DOS oxidation products are located in the region of higher O/C values compared to the DOS, to the direction of carboxylation.
Depending on the nature of the drug interaction, dietary supplements have a delayed effect--augmenting warfarin's natural effect--or an immediate effect--exerting a different effect through a different mechanism (Corrigan & Ulfers, 1981; Megavitamin E Supplementation and Vitamin K-Dependent Carboxylation, 1983; Vitamin K, Vitamin E, and the Coumarin Drugs, 1982).
Influence of the Reactive Extrusion Conditions on the Free Radical Induced Carboxylation of Poly(L-Lactide)
With insufficient vitamin K in the diet, carboxylation is incomplete, and osteocalcin fails in its function of strengthening bone structure.
Main Group elements- and transition metal-promoted carboxylation of organic substrates (alkanes, alkenes, alkynes, aromatics and others)
Salicylic acid influences net photosynthetic rate, carboxylation efficiency, nitrate reductase activity and seed yield in Brassica juncea.
Vitamin K2 is involved in the carboxylation of certain glutamate residues in proteins to form gamma-carboxyglutamate residues (Gla-residues), which in turn activate these proteins.
VKAs are coumarin-like drugs that interfere with the carboxylation of vitamin K-dependent coagulation factors, thus limiting their activity (5).