ACE inhibitor

(redirected from Cardioprotective effects)
Also found in: Dictionary, Thesaurus, Medical.

ACE inhibitor

(ā'sē'ē`, ās) or

angiotensin-converting enzyme inhibitor

(ăn'jēōtĕn`sĭn), drug used to reduce elevated blood pressure (see hypertensionhypertension
or high blood pressure,
elevated blood pressure resulting from an increase in the amount of blood pumped by the heart or from increased resistance to the flow of blood through the small arterial blood vessels (arterioles).
..... Click the link for more information.
), to treat congestive heart failurecongestive heart failure,
inability of the heart to expel sufficient blood to keep pace with the metabolic demands of the body. In the healthy individual the heart can tolerate large increases of workload for a considerable length of time.
..... Click the link for more information.
, and to alleviate strain on hearts damaged as a result of a heart attack (see infarctioninfarction,
blockage of blood circulation to a localized area or organ of the body resulting in tissue death. Infarctions commonly occur in the spleen, kidney, lungs, brain, and heart.
..... Click the link for more information.
). ACE inhibitors block production of an enzyme that helps convert the protein angiotensin 1 into angiotensin 2, a protein that makes blood vessels constrict and promotes retention of fluid, raising blood pressure. Thus ACE inhibitors act to widen the blood vessels and make it easier for the heart to pump blood through the body. captopril (Capoten), ramipril (Altace), and enalapril (Vasotec) are commonly used ACE inhibitors. Angiotensin-receptor blockers (ARBs), such as losartan (Cozaar) and valsartan (Diovan), reduce hypertension by displacing angiotensin 2 from receptors on the surface of cells. ARBs are used as alternatives to the less expensive ACE inhibitors because they have fewer side effects.
References in periodicals archive ?
The present study was designed to investigate the cardioprotective effect of total phenylethanoid glycosides from Monochasma savatieri Franch (TPG).
These results suggest that antiapoptosis might be one of the major mechanisms underlying the cardioprotective effects of Que postconditioning.
When, the only level of nonHDL-C is examined, it is not possible to evaluate the cardioprotective effect of HDL-C.
To demonstrate that ALDH2 activation is sufficient to induce cytoprotection, researchers needed a direct and specific agonist of this enzyme--that is, a molecule that could activate ALDH2 and induce the same cardioprotective effects without the presence of alcohol.
With 287 (574/2) subjects per group, the WHI could not reasonably be expected to provide useful information regarding the cardioprotective effects of E+P in moderately to severely symptomatic women who were 50 to 54 years old at the start of the trial.
Effect of ibuprofen on the cardioprotective effect of aspirin.
Alhough the implications of this pharmacodynamic interaction have yet to be evaluated using clinical end points, evidence of such an interaction is important, "because the cardioprotective effect of aspirin, when used for secondary prevention of myocardial infarction, could be attenuated," the paper said.
These steroid hormones also play an important role in bone maintenance, in the central nervous system, and in the cardiovascular system where estrogens have certain cardioprotective effects (1-3).
The findings presented at AHA highlighted Bendavia's cardioprotective effects and its potential to reduce cardiac dysfunction and compromised performance in several animal models.
Evidence from observational studies suggests that the cardioprotective effects of omega-3 fatty acids can be obtained at relatively low doses, and that little or no additional benefit is achieved by increasing the dose.
The cardioprotective effects may be related to the activation of cNOS, which leads to an increase in NO production and decrease in apoptosis (Zhang et al.
The cardioprotective effects of omega-3 fatty acids appear to be due to a synergism between multiple, intricate mechanisms involving anti-inflammatory and anti-atherosclerotic effects.