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caspase |
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caspase [′kas‚pās] (cell and molecular biology) Any of a family of intracellular proteins that mediate apoptosis. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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This closely regulated, energy-requiring process can be initiated through 2 different mechanisms, each based on the successive activation of preexisting but dormant cysteine-aspartate proteases, or caspases (Figure 1). TNF-[alpha] might trigger apoptosis in hepatocytes by signaling through the Fas-associated death-domain protein of the TNF receptor that activates caspases (Leist et al. The markers attempt to identify and isolate a variety of cell growth factors, like IGF, and the lack of proteins associated with cell death or protein degradation, like caspases that trigger death or heat-shock proteins (HSPs) that start the processes for protein breakdown. |
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