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catenin |
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catenin [′kat·ə·nən] (biochemistry) Any of a family of 80-102-kilodalton proteins that are thought to have a major role in regulation of cell-to-cell adhesion, which is related to their interaction with E-cadherin and the actin cytoskeleton. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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The epithelial cadherin molecules have three main regions- the N-terminal extracellular region, the transmembrane region that spans the cell membrane once, and the C-terminal cytoplasmic region that communicates with the cytoskeletal actin filaments through catenins. Catenins are multifunctional intracellular proteins that not only bind to cell adhesion molecules called cadherins, but also affect gene expression by interacting with nuclear proteins such as steroid receptors. Catenins are critical in the cell-to-cell binding process and play an important role in the maintenance of the structural integrity of a tumor's blood vessels. |
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