28] Papkoff J, Rubinfeld B, Schryver B, Polakis P Wnt-1 reg ulates free pools of catenins
and stabilizes APC-catenin
Adhesive and signaling functions of cadherins and catenins
in vertebrate development.
1), is a transmembrane cell adhesion molecule comprising a cytoplasmic domain, which interacts through intracellular catenins
with the actin-based cytoskeleton, and an extracellular domain, which is involved in homotypic cell-to-cell adhesion.
The [alpha], [beta], p, and [gamma] catenins
play important roles in intercellular signal transduction.
2]-dependent cell adhesion molecules (Takeichi, 1988, 1991; Pouliot, 1992), and are associated with cytoplasmic proteins named catenins
(Hirano et al.
If so, are they catenins
found in those junctions, or where you see the cell-cell staining?
are multifunctional intracellular proteins that not only bind to cell adhesion molecules called cadherins, but also affect gene expression by interacting with nuclear proteins such as steroid receptors.
For Ecadherin--an adhesion molecule forming complexes with catenins
at epithelial cell-cell adherens junctions that is lost during epithelial-to-mesenchymal transition--positive membrane staining is only seen in the epithelial cells, not the stromal cells.
are critical in the cell-to-cell binding process and play an important role in the maintenance of the structural integrity of a tumor's blood vessels.
The [alpha] and [beta] catenins
are complexed with the carboxy-terminal cytoplasmic tail of E-cadherin, whereas the p120 catenin
is anchored to the E-cadherin in a juxtamembranous site.
1,2) The integrity and morphology of epithelial units is maintained by E-cadherin and its undercoat proteins, the catenins
([alpha], [beta], and [gamma]]g), which are associated with the cytoplasmic domain of E-cadherin.
Since the cadherins are known to associate intracellularly with catenins
, we also examined whether [Beta]-catenin
showed a similar pattern of nuclear reactivity in Merkel cell carcinomas.