catenin

(redirected from Catenins)
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catenin

[′kat·ə·nən]
(biochemistry)
Any of a family of 80-102-kilodalton proteins that are thought to have a major role in regulation of cell-to-cell adhesion, which is related to their interaction with E-cadherin and the actin cytoskeleton.
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28] Papkoff J, Rubinfeld B, Schryver B, Polakis P Wnt-1 reg ulates free pools of catenins and stabilizes APC-catenin complexes.
Adhesive and signaling functions of cadherins and catenins in vertebrate development.
1), is a transmembrane cell adhesion molecule comprising a cytoplasmic domain, which interacts through intracellular catenins with the actin-based cytoskeleton, and an extracellular domain, which is involved in homotypic cell-to-cell adhesion.
The [alpha], [beta], p, and [gamma] catenins play important roles in intercellular signal transduction.
If so, are they catenins found in those junctions, or where you see the cell-cell staining?
Catenins are multifunctional intracellular proteins that not only bind to cell adhesion molecules called cadherins, but also affect gene expression by interacting with nuclear proteins such as steroid receptors.
For Ecadherin--an adhesion molecule forming complexes with catenins at epithelial cell-cell adherens junctions that is lost during epithelial-to-mesenchymal transition--positive membrane staining is only seen in the epithelial cells, not the stromal cells.
Catenins are critical in the cell-to-cell binding process and play an important role in the maintenance of the structural integrity of a tumor's blood vessels.
The [alpha] and [beta] catenins are complexed with the carboxy-terminal cytoplasmic tail of E-cadherin, whereas the p120 catenin is anchored to the E-cadherin in a juxtamembranous site.
1,2) The integrity and morphology of epithelial units is maintained by E-cadherin and its undercoat proteins, the catenins ([alpha], [beta], and [gamma]]g), which are associated with the cytoplasmic domain of E-cadherin.
Since the cadherins are known to associate intracellularly with catenins, we also examined whether [Beta]-catenin showed a similar pattern of nuclear reactivity in Merkel cell carcinomas.