The [alpha] and [beta] catenins are complexed with the carboxy-terminal cytoplasmic tail of E-cadherin, whereas the p120 catenin is anchored to the E-cadherin in a juxtamembranous site.
Lobular versus ductal breast neoplasms: the diagnostic utility of p120 catenin.
are multifunctional intracellular proteins that not only bind to cell adhesion molecules called cadherins, but also affect gene expression by interacting with nuclear proteins such as steroid receptors.
1,2) The integrity and morphology of epithelial units is maintained by E-cadherin and its undercoat proteins, the catenins ([alpha], [beta], and [gamma]]g), which are associated with the cytoplasmic domain of E-cadherin.
The epithelial cells express E-cadherin and catenins ([alpha], [beta], and [gamma]), whereas the spindle cells react to vimentin focally and to N-cadherin.
Catenins are critical in the cell-to-cell binding process and play an important role in the maintenance of the structural integrity of a tumor's blood vessels.
This patent, Adherex's 25th issued in the US, targets a distinct family of molecules inside cells called catenins and opens up the possibilities of a new realm of further therapeutic applications and a completely novel way to attack and destroy the blood vessels that feed a tumor.
1) They are linked to the actin-based cytoskeleton by a group of proteins called catenins
([alpha]-, [beta]-, and [gamma]-catenins
; plakoglobin; vinculin; and [alpha]-actinin).
Since the cadherins are known to associate intracellularly with catenins
, we also examined whether [Beta]-catenin
showed a similar pattern of nuclear reactivity in Merkel cell carcinomas.
1) The cytoplasmic domain of the cadherin molecule is complexed to a variety of molecules, including members of the catenin
family, which link the cadherin to the actin cytoskeleton of the cell and may facilitate binding of the cadherin molecule to the cell surface.