Cathepsins


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Related to Cathepsins: Cathepsin L

Cathepsins

 

intracellular proteinases of the hydrolase class that catalyze the hydrolysis of the peptide bond in peptides and proteins.

Cathepsins are widely distributed in animal and plant tissues and in microorganisms. Cathepsins are divided according to the character and specificity of enzymic action into endopeptidases, which are capable of hydrolyzing internal peptide bonds in the molecules of proteins and peptides, and exopeptidases, which act solely on compounds with one or more free terminal carboxyl or amino groups. Cathepsins can also catalyze reactions that may result in lengthening the peptide chain. Almost all cathepsins are activated by compounds containing sulfhydryl groups (cysteine, glutathione).

References in periodicals archive ?
Cathepsin K-dependent toll-like receptor 9 signalling revealed in experimental arthritis.
Emerging roles of cysteine cathepsins in disease and their potential as drug targets.
Also semi-quantifications of proteins by electrophoresis and proteolytic activities by mono-dimensional zymography for metalloproteases and cathepsins have been reported in order to study the effect of chilling rates on the quality features of fatty livers.
Libby, "Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells," The Journal of Clinical Investigation, vol.
Excess intralysosomal iron-catalyzed ROS may cause LMP, whereby lysosomal cathepsins like cathepsin B are released from the lysosomal lumen to the cytosol, and resultantly trigger MMP.
Results: As results, E2 and BPA upregulated the protein expression of vimentin, cathepsin D, and MMP-2, but downregulated the protein expression of E-cadherin via ER signaling pathway, suggesting that E2 and BPA promote EMT and cell migration related gene expressions.
Key words: goatling, metabolism, myofibrillar toughness, tenderness, pH, cathepsins.
In addition, LDL particles interact with proteoglycans (biglycan and decorin) and form aggregates, with a catalytic activity of sphingomyelinase, cathepsin D, cathepsin F and lysosomal acid lipase [15].
Another protein, cathepsin B is involved in all stages of neoplastic transformation, such as tumor growth, angiogenesis, invasion and metastasis.
Cystatin C, is a small ubiquitously expressed protein found in nearly all body fluids, and is the most potent endogenous extracellular inhibitor of cysteine cathepsins [91].
Physarolisins as well as arabidopsins are the only major intracellular enzymes, in addition to cathepsins D and E, among the three types of peptidases studied, and elucidation of their physiological roles is awaited.