Cellular adhesion

Cellular adhesion

The process whereby cells interact and attach to other cells or to inanimate surfaces, mediated by interactions between the molecules on the surface of the cell. This process has been studied extensively in embryonic cells of higher organisms, where species and tissue specificity of adhesion has been shown. However, adhesion is a common feature in the life of most organisms.

Prokaryotic microorganisms do not frequently exhibit cell-to-cell interactions, but adhere to surfaces forming biofilms. In these interactions with a surface, some microorganisms cause corrosion of metal by adhering and producing corrosive acid by-products as a result of their metabolism. Adhesion of microorganisms to the cells of higher plants and animals is often a prerequisite for causing disease. Eukaryotic microorganisms often exhibit specific cell-to-cell interactions, allowing complex colonial forms and multicellular organisms to be constructed from individual or free-living cells. Adhesion between different plant cells is apparent in several cases, as in the interaction between a pollen grain and the stigma during fertilization.

Interactions between two cell surfaces may be quite specific, involving certain types of cell-surface protein molecules, or general, involving production of a sticky extracellular matrix that surrounds the cell, as frequently occurs in bacterial adhesion. Cellular adhesion is important in cellular recognition, in the generation of form or pattern, and possibly in regulation of cellular differentiation. See Cell (biology), Cell differentiation

All adhesion is mediated by the cell surface, either directly involving integral components of the plasma membrane, or indirectly through material excreted and deposited on the outside of the cell. Most theories of cellular adhesion suggest that cell-surface glycoproteins serve as ligands involved in attaching cell surfaces together. When a specific cell interacts with an identical cell, the attachment is said to be homotypic. Heterotypic adhesion involves interactions between different cell types. If the ligand-specific attachment involves interaction between identical cell-surface ligands, it is homophilic, and between two different ligands, heterophilic. The interaction between a pollen grain and the stigma cells described previously is an example of a heterotypic, heterophilic interaction.

Many studies of species and tissue specificity have been done with embryonic chick and mouse systems. In general, it would seem that homotypic adhesion is stronger that heterotypic adhesion. Also, tissue and species specific adhesion can be shown, but tissue specificity seems to be more frequent. For example, when dissociated embryonic neural retina of mouse and chick are mixed and allowed to aggregate, there is very little sorting, and mosaic tissue is formed. This is not true in all tissues, as heart and liver tissue show much greater species specificity than neural retina.

Throughout development, it is necessary for specific adhesion among cells to establish and maintain form. It is also important during development that cells change position, as occurs during gastrulation, or migrate, as with neural crest cells that move from the neural tube to various positions, forming ganglia. In these cases, it would seem to be necessary for certain cells to dissociate or alter their adhesive properties in response to the proper developmental cues. Throughout development, there are a series of primary and secondary inductions that affect cellular differentiation and pattern formation. These inductions depend on interactions between cell types having different histories, either due to being in different embryonic layers or due to interaction between cells derived from the same layer but previously differentiated. These changes in form are related to specific changes in cell-adhesion molecules.

References in periodicals archive ?
The removable magnet housing features a protective coating to prevent unwanted cellular adhesion, simplifying the removal and replacement of the implant magnet.
The investigational drug candidate, designed to inhibit a major cellular adhesion receptor (CD29) that is fundamental for progression of aggressive and resistant cancer tumors, was granted orphan drug designation by the U.
In further research, the group implanted human prostate cancer cells in mice and observed that cellular adhesion increased with the administration of genistein.
The contribution of different mechanobiological mechanisms by which cells react to mechanical signals will be identified by selectively inhibiting cellular adhesion, contractility, and mechanotransduction pathways.
36] Recent studies have examined the role of cellular adhesion molecules in tumor metastasis, but no correlation was noted in the expression or distribution of various cellular adhesion molecules by the different histologic subtypes of basal cell carcinoma.
The new research, she says, "has the implication that other cellular adhesion molecules may well be major receptors for other, much more pathogenic viruses.
In aggressive tumors, EMT is characterized by reduced expression of E-cadherin and increased N-cadherin expression, which contributes to a more stromal cellular adhesion profile and increased tumor cell motility and invasive properties.
The researchers screened 50,000 compounds to find those affecting cellular adhesion and then analyzed the compounds for toxicity and for the effects on actin, a protein essential to cellular structures.
Further investigation found that DAL produces these effects by decreasing the activity of Rac1, a protein known to be important to cellular adhesion and cytoskeletal organization.
Test results have confirmed that fluorapatite nanoparticles have low solubility, desirable cellular adhesion, and suitable phosphate activity.
Cellular adhesion molecules expression was increased at the level of the keratinocytes, endothelial cells, and dendritic cells.
The outcomes were FMD and markers of endothelial dysfunction, including cellular adhesion molecules, inhibitors and promoters of fibrinolysis, adiponectin, glucose, insulin, C-reactive protein (CRP), lipids, and apolipoprotein B.