The above mentioned process is in part mediated by cellular adhesion molecules
(CAMs), which attach to the endothelial cell membrane in response to activation by various inflammatory cytokines, like interleukin-1, tumor necrosis factor, and interferon2.
It is well-known that cellular adhesion molecules
have effects on tumor cell invasion and metastasis.
leprae, lesional infiltration by activated T cells, enhanced local expression of inflammatory cytokines such as TNF-a and cellular adhesion molecules
, increased local macrophage activation and increases in levels of pro-inflammatory circulating cytokines in the blood.
If future studies confirm our results, cellular adhesion molecules
may be potential targets to prevent restenosis in clinical practice.
5) These contradictory results encouraged us to perform a study to determine the expression of select proto-oncogenes and cellular adhesion molecules
, with a view to defining a marker that helped identify a biologically aggressive neoplasm.
The outcomes were FMD and markers of endothelial dysfunction, including cellular adhesion molecules
, inhibitors and promoters of fibrinolysis, adiponectin, glucose, insulin, C-reactive protein (CRP), lipids, and apolipoprotein B.
The recruitment of these inflammatory cells and their transendothelial migration is mediated by the cellular adhesion molecules
(CAMs), which are expressed by endothelial cells and circulating leukocytes (monocytes and linfocytes) in response to different inflammatory stimuli (Davies et al.
Several circulating inflammation factors such as cellular adhesion molecules
and cytokines are associated with cardiovascular disease (8,12,13).
Host defenses to extravascular infections usually elicit proinflammatory cytokines and stimulate increased expression of cellular adhesion molecules
, enhancing leukocyte adhesion.
The new research, she says, "has the implication that other cellular adhesion molecules
may well be major receptors for other, much more pathogenic viruses.
Cytokine-induced expression of cellular adhesion molecules
was measured on primary human coronary artery endothelial cell (HCAEC) cultures.