Based on the constellation of findings, we speculate that the intercellular staining observed in this bullous pemphigoid case is not real IgG4 immunoreactivity, but resulted from nonspecifically stained exudate permeating into the spongiotic cellular junction
, mimicking intercellular junctional immunostain.
This long-awaited, first comprehensive book on this topic of fundamental importance in our understanding of cancer begins with an overview of cellular junctions
, before covering cell-matrix junctions, cell-cell junctions and cell-matrix and cell-cell adhesion in separate sections.
Following injection, Alkermes believes that RMP-7 binds to receptors on these barriers and triggers a brief relaxation of their tight cellular junctions