Ceruloplasmin


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ceruloplasmin

[sə¦rül·ō¦plaz·mən]
(biochemistry)
The copper-binding serum protein in human blood.

Ceruloplasmin

 

a copper-containing protein of the α2-globulin fraction of blood plasma. It was first discovered and isolated by the Swedish scientists C. Holmberg and C. Laurell in 1948. Its content in human plasma is 0.2–0.3 mg/ml. Ceruloplas-min, which has a molecular weight of 130,000, is bound to 60–99 percent of all the plasma copper ions. Its two molecular forms differ in the number of carbohydrate chains, which consist of galactose, mannose, fucose, N-acetylglucosamine, and sialic-acid residues. Ceruloplasmin has some catalytic activity, oxidizing polyamines, polyphenols, and ascorbic acid (vitamin C). It also takes part in hematopoiesis and the transport of copper to sites where other copper-containing proteins, such as cytochromoe oxidases, are synthesized. In addition, it apparently participates in the regulation of the level of biogenic amines.

There exist genetically determined variants of ceruloplasmin caused by the presence of mutant alleles. The level of ceruloplas-min in blood serum increases nonspecifically during pregnancy, infections, anemias, and malignancies but decreases during the Wilson-Konovalov disease and some other diseases.

N. N. CHERNOV

References in periodicals archive ?
When ceruloplasmin is measured by the immunologic method (the one most used clinically), the normal range of free copper is 5 to 15 mcg/d1, but it may be very low or even less than 0.
Aceruloplasminemia is an autosomal recessive disorder characterized by a lack of ceruloplasmin ferroxidase activity important for iron conversion and exportation.
Some metals binds with proteins having a specific transport function such as transferring or ceruloplasmin.
Newly absorbed iron, or iron released from ferritin, is converted from ferrous to ferric iron by ceruloplasmin, transferred to apotransferrin in the cell, and then released into the circulation as transferrin.
There were no significant differences in GST activity and ceruloplasmin between groups either before the beginning of the study or after three months.
64) "The pomegranate extract-induced increase in ceruloplasmin activity can be expected to strengthen antioxidant defenses," noted investigators.
9) Significant aspects of this response are ensuing fever, loss of appetite, listlessness, increased serum copper concentrations, sequestration of iron and zinc, metabolic alteration, and increased synthesis of C-reactive protein, fibrinogen and ceruloplasmin.
By maintaining transition metals in a relatively low-redox state, metal-binding proteins, including ferritin, transferrin, the metallothioneins, and ceruloplasmin, contribute significantly to the antioxidant protection of tissues and body fluids.
Almost all patients with Wilson's Disease also have a decreased level of serum ceruloplasmin, a copper binding protein, in their blood.
2 seconds, Cu 134 U/L (70-153 U/L) and ceruloplasmin 409 U/L (280-570 U/L).
A ceruloplasmin test is helpful to screen for Wilson's disease, an uncommon disease of copper metabolism that usually presents in childhood or early adulthood, although there have been case reports of diagnosis in people in their 50s and 60s.