Chagas Disease

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Chagas’ Disease


(also called American trypanosomiasis), a transmissible parasitic disease of humans and animals caused by trypanosomes. The disease was described in 1909 in Brazil (state of Minas Gerais) by the physician C. Chagas. It occurs in Central and South America, chiefly among the poorest strata of the population, who live in dwellings infested by transmitters of the disease (bloodsucking hemipterous insects, mainly triatomids). Humans and wild and domestic animals suffering from Chagas’ disease are the sources of infection.

Infection occurs when the causative agent, together with insect feces, enters injured skin or the mucous membranes of the eyes, nose, and mouth. The main symptoms are fever and enlargement of the lymph nodes in the acute stage, with involvement of the heart and gastrointestinal tract when the disease becomes chronic. The main methods for controlling Chagas’ disease are improvement of social and living conditions of the people, disinsectization, and destruction of infected animals.

References in periodicals archive ?
This US approval of benznidazole for Chagas disease was gained with cooperation and close collaboration with its US-based pharmaceutical division Exeltis, corporate social responsibility partner Mundo Sano as well as the Drugs for Neglected Diseases initiative (DNDi).
Chagas disease screening in maternal donors of publicly banked umbilical cord blood, United States.
The National Chagas Program (NCP) in Argentina (7) seeks to optimize early diagnosis and timely treatment of acute and chronic Chagas infection, through design and distribution of patient care guidelines (8) and the purchase and free distribution of trypanocidal medication by the Argentine Ministry of Health to provincial Chagas disease programs.
cruzi as a potential opportunistic parasite in HIV patients from areas where Chagas disease is endemic, (16) such as southern Rio Grande do Sul, Brazil.
He was strongly encouraged to seek follow-up in the civilian health care sector and to notify household contacts that they should be screened for Chagas disease.
Even though the aforementioned combative actions were successful in reducing the Chagas disease, a new problem has emerged.
Prevalence of Chagas disease in Latin-American migrants living in Europe: a systematic review and meta-analysis.
The report reviews key players involved in the therapeutics development for Chagas Disease (American Trypanosomiasis) and enlists all their major and minor projects
Chagas Disease is caused by the parasite Trypanosoma cruzi transmitted primarily by insects known as "kissing bugs.
Chagas disease is mainly transmitted by Reduvidae hematophagous insects that upon feeding on an infected mammal ingest blood trypomastigotes that, in the insect gut, will transform to epimastigotes, the replicative extracellular forms of the parasite (Jimenez et al.
Chagas disease is transmitted by the bite of the assassin bug or vinchuca and is particularly endemic in poorer areas of Latin America and the Caribbean.