This trial enrolled patients who, at baseline, were treatment naive to beta-blockers, diuretics, statins and calcium channel blockers
, the latter being used as metabolically neutral controls.
The effects of calcium channel blockers
on the cardiovascular system include decrease in electromechanical contruction in the myocardium, slowing down of the "pacemaker" activity, decrease in the atrioventricular conduction and dilatation in vascular smooth muscles (2).
MET guidelines concur that alpha-blockers are effective, while there is insufficient evidence to recommend the regular use of calcium channel blockers
, corticosteroids, or PDE5 inhibitors as a monotherapy.
The major disadvantage is cost but there are generic ACE-inhibitors and calcium channel blockers
on the market, which helps.
However, long-acting calcium channel blockers
have been found to be generally safe and effective (Eisenberg, Brox, and Bestawros, 2004).
NEW ORLEANS -- Calcium channel blockers
and diuretics are the best drugs for treating hypertension in elderly patients because they are the most effective at reducing the risk of what they fear most: stroke, Dr.
The cardiovascular drugs that have the most favorable profile would be the class of alpha-blockers, ACE inhibitors and ARBs--venodilators, nitrates and slow calcium channel blockers
(with the exception of verapamil, which may cause a significant decrease in heart rate response at peak exercise.
Commonly recommended medications include beta blockers, calcium channel blockers
and tricyclic antidepressants.
The beneficial effect of calcium channel blockers
is mediated via their peripheral vasodilatory, antiplatelet, and antileukocytic effects.
Long-acting calcium channel blockers
are significantly less effective than other antihypertensive agents in reducing the disease's major cardiovascular complications, according to a new metaanalysis.
A large-scale study in Sweden found a significant link between the use of calcium channel blockers
and the incidence of suicide.
The researchers had raised the question about the relative safety of calcium channel blockers