Chemotherapeutic Agent


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Related to Chemotherapeutic Agent: chemotherapy

Chemotherapeutic Agent

 

the name given to various groups of drugs used in chemotherapy and chemoprophylaxis. Chemotherapeutic agents include substances of natural origin (for example, antibiotics) and synthetic preparations (for example, sulfanilamides, nitrofurans, and para-aminosalicylic acid). Antimicrobial, antiparasitic, and antineoplastic chemotherapeutic agents are distinguished. With the discovery and use of sulfanilamides (G. Domagk) and antibiotics (A. Fleming, H. Florey, and E. Chain) in the 1930’s and 1940’s, chemotherapeutic agents became the principal means of treating infectious diseases. In the 1940’s and 1950’s nitrogen mustard and many other agents became important in the treatment of malignant tumors.

References in periodicals archive ?
Many chemotherapeutic agents are specifically designed to stop rapid cell proliferation; therefore, it is reasonable to predict that cancer drugs would harm a developing fetus," Ms.
Pgp acts to rapidly pump a large number of hydrophobic and heterocyclic cancer chemotherapeutic agents including adriamycin (doxorubicin), colchicine, colcemid, etoposide, taxol, vincristine and vinblastine out of the tumor cells, thereby preventing accumulation within the cells of effective levels of the chemotherapeutic agents.
The researchers gave a single dose of the chemotherapeutic agent 5-fluorouracil to mice, and the next day gave some of the mice an infusion of purified myeloid progenitor cells.
Human colon and breast xenography are being used to optimize formulations and results show that DAVANAT(R) exhibits a broad spectrum of activity with chemotherapeutic agents.
Vestar's patent covers the targeting to tumors of liposomes containing chemotherapeutic agents.
Local chemotherapeutic agents offer an additional mode of therapy and should be used on a case-to-case basis, not necessarily as an initial treatment.
Another advantage of these organoapatite mixtures is their ability to blend with other useful substances, such as antibiotics, anti-inflammatory and chemotherapeutic agents, or growth factors, which stimulate healing and tissue repair.
One of our endothelinB agonists was shown to improve tumor blood perfusion, to enhance delivery of chemotherapeutic agents to the tumor tissue and to increase the effectiveness of anti-cancer drugs in an animal model of breast tumor.
AmpliMed's multi-center studies using a combination of Amplimexon[R] and common chemotherapeutic agents in Stage IV metastatic melanoma (Phase II) and advanced pancreatic adenocarcinoma (Phase Ib) are scheduled to be completed early next year.
In January 2006, Endocyte also entered into a licensing agreement with Bristol-Myers Squibb for the development of targeted epothilone-based chemotherapeutic agents.
Researchers from the National Cancer Institute and six cancer hospitals in the United States and Italy report that the risk of bone cancer among survivors of a variety of childhood cancers rises sharply with increasing exposure to radiation or certain chemotherapeutic agents, reaching 40-fold at some of the highest doses used.