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chenodeoxycholic acid |
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chenodeoxycholic acid [¦kē·nō‚dē‚äk·sē¦kō·lik ′as·əd] (biochemistry) C24H40O4A constituent of bile; needlelike crystals with a melting point of 119°C; soluble in alcohol, methanol, and acetic acid; used on an experimental basis to prevent and dissolve gallstones. Also known as anthropodesoxycholic acid; chenic acid; gallodesoxycholic acid. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Short of surgery, the only gallstone therapy currently approved in the United States is treatment with chenodeoxycholic acid. Oral administration of UDCA in humans leads to a significant change in the relative proportions of the biliary and serum bile acids, such that UDCA becomes the major bile constituent (about 50 percent when a 13-15 mg/kg/day dose is given) and naturally replaces cholic and chenodeoxycholic acids. |
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