ibuprofen

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ibuprofen

(ī`byo͞oprō'fən), nonsteroidal anti-inflammatory drug (NSAID) that reduces pain, fever, and inflammation. Along with naproxennaproxen
and naproxen sodium,
potent nonsteroidal anti-inflammatory drugs (NSAID) used to alleviate the minor pain of arthritis, menstruation, headaches, and the like, and to reduce fever.
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 and ketoprofenketoprofen
, nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and fever-reducing effects, used to relieve the symptoms of headaches, arthritis, and painful menstruation.
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, ibuprofen belongs to the propionic acid class of NSAIDs. It was first made available in 1967. Like other NSAIDs, it acts by inhibiting the body's production of prostaglandinsprostaglandin
, any of a group of about a dozen compounds synthesized from fatty acids in mammals as well as in lower animals. Prostaglandins are highly potent substances that are not stored but are produced as needed by cell membranes in virtually every body tissue.
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. Available over the counter in a variety of preparations (e.g., Advil, Motrin, Nuprin), it is commonly used to treat rheumatoid arthritis, gout, and painful menstruation. Side effects include rash, alteration of platelet function and bleeding, and intestinal upset, which can lead to gastritis. Like other NSAIDS, it appears to have no potential for abuse or physical dependence. It should not be used by those who are allergic to aspirin.
References in periodicals archive ?
Children's Advil relieves fever and minor aches and pains due to the cold and flu for children ages 2-11.
The FDA's action last week validates our point that stronger label warnings were needed on over-the-counter products such as Children's Advil and Children's Motrin," said Barber.
It currently has lawsuits pending against the makers of Children's Advil, and the NSAID diflunisal (Dolobid), as well as the antibiotics Zithromax and Amoxicillin, a synthetic penicillin.
Three-year-old Heather was given Children's Advil on or about March 1, 2003, after developing a fever.
The suit alleges that Children's Advil caused Heather Kiss to develop SJS, resulting in serious and permanently disabling injuries and death on March 17, 2003.
Additionally, Wyeth had cases of SJS that occurred in the study that supported the approval of the OTC Children's Advil, but failed to disclose this to physicians or consumers.
Patients received either Children's Advil Suspension or Children's Tylenol(R) under the observation of a physician, and researchers conducted follow-up interviews approximately two weeks after treatment.

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