These methods construct deoxypropionate units in a linear-iterative fashion, and one iteration cycle typically requires 3-6 steps to introduce one methyl-branched chiral center
WaVe, which aims to control the chirality of nucleic acid therapeutics, will initially focus on oligonucleotides nucleic acid strings in which each phosphorothioate modification introduces a new chiral center
The nerolidol molecule contains a chiral center
and a double bond-generating cis/trans isomerism, resulting in four possible stereoisomers in a mixture.
Therefore, the phosphorus atom can act as a chiral center
unlike a nitrogen atom.
Since chiral center
is present in the side chain of d-TRS.
Finally, some of the newest results indicate the possibility to induce chirality in nonchiral liquid crystalline azobenzene polymers, even in the absence of any structural chiral center
, simply by irradiating with appropriate circularly polarized light.
Dimebu (3,3-dimethylbutyl methylphosphonofluoridate) (5), an isomer of soman with only one chiral center
, P([+ or -]), is also hydrolyzed by IBA-[Beta]CD.
In addition, they can be used to predict the absolute configuration of the chiral center
in many instances.
Later a new synthetic strategy was developed which involved the introduction of the chiral center
in the very first step using an enantiomerically pure amino acid which led to the synthesis of enantiomerically pure quinazolinones nucleus.
Many chemical compounds used in the formulation of drugs have one or a few chiral centers
In order to provide the cyanohydrins, first sulfonic is produced which is a sediment and then by adding potassium cyanide to the sulfonic compound, the nitrile group is replaced and the compound of 4-t-butyl-2-(Npiperidinomethyl)cyanocyclohexane is obtained which had active optical chiral centers
and is a new analog of active optical cyanohydrin family.
L-(+)- tartaric acid is a readily available chemical, contains two chiral centers
and has also been used enormously in the synthesis of chiral and bioactive compounds [1-7].