Chlorogenic Acid

Also found in: Wikipedia.

chlorogenic acid

[¦klȯr·ə¦jen·ik ′as·əd]
C16H18O9 An important factor in plant metabolism; isolated from green coffee beans; the hemihydrate crystallizes in needlelike crystals from water.

Chlorogenic Acid


C16H18O9, a complex ester of caffeic acid with one of the stereoisomers of quinic acid. It is obtained in the form of colorless crystals, which have a melting point of 206°–210°C and are readily soluble in water. Alkaline solutions of chlorogenic acid turn green in the air (hence the name). It is very common among the higher plants, frequently occurring together with its isomer isochlorogenic acid. It is contained in large quantities in germinating sunflower seeds and in green coffee beans. Chlorogenic acid probably plays a part in regulating the ripening of fruits by acting on the respiration of the fruits as an inhibitor of oxidative phosphorylation. It is toxic to some pathogenic microorganisms that cause a number of plant diseases, such as potato scab and wilt disease. In a number of plants, for example, rice, the biosynthesis of chlorogenic acid increases in response to a microbial infection.

Mentioned in ?
References in periodicals archive ?
Furthermore, chlorogenic acid has been associated with a reduction in the risk of mortality due to inflammation.
Researchers sought to evaluate the effect of a combined nutraceutical containing berberine, chlorogenic acid and tocotrienols.
The most important type of green coffee is the Arabic coffee, which contains what is known as chlorogenic acid used for the purpose of weight loss, but unfortunately, roasting coffee loses 70 percent of this acid and thereby, loses its ability to reduce weight.
Scientists have found that chlorogenic acid, or CGA, significantly reduced insulin resistance and accumulation of fat in the livers of mice who were fed a high-fat diet.
In another study done by the University of Georgia, which was published in Pharmaceutical Research, chlorogenic acid present in the coffee reduces the insulin resistance and fat level in the body.
Benefits in weight management are due to two active compounds, caffeine and chlorogenic acid (which is destroyed by roasting).
This can be attributed to the chlorogenic acid found in the unroasted coffee beans.
Raw coffee is, on average, just 1 percent caffeine, but it contains 7 to 9 percent chlorogenic acid, a strong antioxidant that prevents retinal degeneration in mice, according to the Cornell study.
Chinese scientists examined the antimicrobial effect of chlorogenic acid on S.
Using as biosensor Chromobacterium violaceum ATCC 31532 and Escherichia coli pSB403, the compounds chlorogenic acid (2), isoorientin (3), orientin (4), isovitexin (6), vitexin (7), and rutin (9) were identified as QS inhibitors.
Chlorogenic acid (CGA), one coffee polyphenol, is the main ingredient in scores of dietary supplements promoted as weight-loss products.