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chlorzoxazone

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chlorzoxazone [klȯr′zäks·ə‚zōn]
(pharmacology)
C7H4ClNO2Crystals with a melting point of 191-191.5°C; soluble in aqueous solutions of alkali hydroxides and in ammonia; used as a skeletal muscle relaxant.
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The warning letter also stated that regarding cleaning validation that cleaning validation was performed for the process trains without evaluating for sample recovery for numerous products, including: Amidal Nasal Decongestant; Amigesic Caplets, 750mg; Carisoprodol and Aspirin Tablets, USP, 200mg/325mg; Carisoprodol Tablets, USP, 350mg; Chlorzoxazone Tablets, USP, 250mg and 500mg; Digoxin Tablets, USP, 0.
Actavis Totowa, Little Falls, NJ, Feb. 1 (Parsippany, NJ) by Warning Letter Bulletin
The warning letter also stated that regarding cleaning validation that cleaning validation was performed for the process trains without evaluating for sample recovery for numerous products, including: Amidal Nasal Decongestant; Amigesic Caplets, 750mg; Carisoprodol and Aspirin tablets, USP, 200mg/325mg; Carisoprodol tablets, USP, 350mg; Chlorzoxazone tablets, USP, 250mg and 500mg; Digoxin tablets, USP, 0.
Actavis Totowa nets warning for QC, cleaning validation by Pickett, Joseph / Validation Times
Chlorzoxazone (CHZ) is a centrally acting muscle relaxant drug that has been used extensively as a selective probe for CYP2E1 phenotyping; this isoform is the main enzyme involved in its 6-hydroxylation (6OH-CHZ) in humans (Lucas et al.
Occupational toluene exposure induces cytochrome P450 2E1 mRNA ... by Albores, Arnulfo / Environmental Health Perspectives
 
 
 
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