Cholesterol-Lowering Drugs

Cholesterol-Lowering Drugs

 

medicinal substances that lower the level of cholesterol in the blood and are used to treat and prevent atherosclerosis. Three main groups of cholesterol-lowering drugs are distinguished according to their mechanism of action: those that interfere with the absorption of cholesterol from the intestine, those that block the synthesis of cholesterol, and those that intensify the excretion and breakdown of cholesterol.

The first group includes preparations containing plant sterols (for example, betasitosterol), which act on the basis of competitive antagonism to cholesterol, and some substances containing saponins (for example, diosponin), whose interaction with cholesterol forms poorly soluble complexes. The second group includes acetic acid derivatives (for example, phenexan and cetamiphenum), which slow cholesterol synthesis. The best-known preparations of the third group are d-thyroxine and thyroxine-like substances.

Preparations and oils containing unsaturated fatty acids (linetol, corn oil) also lower cholesterol levels. Blood cholesterol sometimes decreases following the use of neurotropic drugs (for example, amytal sodium, phenobarbital, chloral hydrate, chlorpromazine hydrochloride, tropaphenum, and hexamethonium benzosulfenas), vitamins C, B6, B12, E, and PP, some drugs that stimulate the flow of bile from the liver, and male sex hormones.

REFERENCES

Miasnikov, A. L. Ateroskleroz. Moscow, 1960.
Mashkovskii, M. D. Lekarstvennye sredstva, 6th ed., part 1. Moscow, 1967.

R. I. KVASNOI

References in periodicals archive ?
What can be expected from the cholesterol-lowering drugs market?
The AHA adopted a new approach "that, in its own words meant cholesterol-lowering drugs could be prescribed to an estimated 33 million Americans without cardiovascular disease who have a 7.
Based on results from five major clinical trials, the new guidelines change the 2001 guidelines that called for physicians to prescribe cholesterol-lowering drugs to reduce LDL cholesterol levels to less than 100 mg/dL in high-risk patients.
Suzanne now takes cholesterol-lowering drugs and is careful to lead a healthy lifestyle to keep her cholesterol as low as possible.
Summary: Cholesterol-lowering drugs taken by millions of Britons could cause a range of serious side-effects, new research suggests.
Statins, a class of cholesterol-lowering drugs, are the most frequently prescribed medicines in the U.
Cholesterol-lowering drugs called statins might be slowing the formation of certain kinds of cataracts in people taking the drugs.
No association appears to exist between age-related macular degeneration and the use of statins or other cholesterol-lowering drugs, according to findings from a case-control study of patients in the Cardiovascular Health Study.
Now research published in the Journal of Neurology, Neurosurgery and Psychiatry also suggests cholesterol-lowering drugs have an impact on the loss of brain function seen in Alzheimer's patients.
The FDA added that recommended doses of cholesterol-lowering drugs - or statins - including Crestor could not cause or worsen kidney failure.
The findings show benefits of treating patients who recently have suffered acute coronary syndromes with higher doses of the cholesterol-lowering drugs called statins soon after they experience heart-attack symptoms.
Nonstatin cholesterol-lowering drugs were also associated with a reduced risk of having open-angle glaucoma.

Full browser ?