Chorea

chorea (kərē`ə, kō–) or St. Vitus's dance, acute disturbance of the central nervous system characterized by involuntary muscular movements of the face and extremities. The disease, known also as Sydenham's chorea (not to be confused with Huntington's disease, a hereditary disease of adults that is sometimes called Huntington's chorea), is usually, but not always, a complication of rheumatic fever. Sydenham's chorea, a disease of children, especially females, usually appears between the ages of 7 and 14. Facial grimacing and jerking movements persist for 6 to 10 weeks and sometimes recur after months or even years. Eventually the symptoms disappear. Although there is no specific treatment, sedatives and tranquilizers are helpful in suppressing the involuntary movements. Technically, it is sometimes called chorea minor or juvenile chorea to distinguish it from several less common choreas, chorea also being a general term for continuous, involuntary jerking movements.

---

chorea

Neurological disorder causing irregular, involuntary, purposeless movements. It is believed to be caused by degeneration of the basal ganglia in the cerebral cortex. Sydenham chorea (St. Vitus dance) is usually associated with rheumatic fever. It usually occurs between ages 5 and 15, more often in girls. Typical jerking movements, mostly in the extremities and face, may affect speech and swallowing and range from mild to incapacitating; attacks last several weeks and recur frequently. Senile chorea, a progressive disease resembling Sydenham chorea, usually occurs late in life. Huntington chorea is rare, hereditary, and fatal. It usually begins between ages 35 and 50 and progresses to random, often violent, and eventually totally incapacitating spasms, absent only during sleep. Mental deterioration begins later, and death occurs in 10–20 years. There is no effective therapy. Children of those afflicted have a 50% chance of developing the illness.

---

chorea

a disorder of the central nervous system characterized by uncontrollable irregular brief jerky movements

---

chorea [kə′rē·ə]

(medicine)

A nervous disorder seen as part of a syndrome following an organic dysfunction or an infection and characterized by irregular, involuntary movements of the body, especially of the face and extremities.

---

Chorea 

a form of hyperkinesia characterized by rapid movements such as twitching of the extremities, winking, and smacking of the lips. It is associated with organic injury to certain subcortical sections of the brain. The most common form is chorea minor, or Sydenham’s chorea, usually found in children and adolescents as an indication of rheumatism. In addition to hyperkinesia, other characteristics of chorea are low muscle tone and such asthenic symptoms as sleeplessness, lacrimation, and irritability. Sydenham’s chorea usually takes a favorable course, but recurrences are possible. The condition known as chorea major, marked by hysterical choreiform twitchings that were observed as a mass phenomenon in the Middle Ages, is now of historical interest only.

Huntington’s chorea (described in 1872 by the American psychiatrist G. Huntington) is a hereditary degenerative disease transmitted as an autosomal dominant trait. It usually occurs between the ages of 35 and 40 and is characterized by chronic progressive deterioration. Muscle tone is low in some cases, and high (with muscular rigidity) in others. The principal characteristics of Huntington’s chorea are such forms of mental deterioration as apathy, loss of memory, intellectual decline, transient delusions, hallucinations, and the gradual development of severe dementia. Other findings in Huntington’s chorea include subcortical lesions and atrophy of the brain cortex.

Sydenham’s chorea is treated with antirheumatic drugs (including salicylates), sedatives, and antiallergens (such as diphenhydramine and chloropyramine). Chlorpromazine and reserpine are prescribed for Huntington’s chorea; drugs used in the case of muscular rigidity include cholinolytic agents (such as trihexyphenidyl hydrochloride), L-dopa, and amantadine hydrochloride.

REFERENCES

Anosov, N. N. “Khoreia Khantingtona.” In Mnogotomnoe rukovodstvopo nevrologii, vol. 7. Leningrad, 1960.
Tsuker, M. B. Infektsionnye zabolevaniia nervnoi sistemy u detei. Moscow, 1963.
Hittyk, L. S. Mala khoreia. Kiev, 1965.

V. A. KARLOV