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Chromatid
(redirected from Chromatids)

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chromatid (krō`mətəd): see chromosome chromosome , structural carrier of hereditary characteristics, found in the nucleus of every cell and so named for its readiness to absorb dyes. The term chromosome
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; crossing over crossing over, process in genetics by which the two chromosomes of a homologous pair exchange equal segments with each other. Crossing over occurs in the first division of meiosis. At that stage each chromosome has replicated into two strands called sister chromatids.
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chromatid [′krō·mə·təd]
(cell and molecular biology)
One of the pair of strands formed by longitudinal splitting of a chromosome which are joined by a single centromere in somatic cells during mitosis.
One of a tetrad of strands formed by longitudinal splitting of paired chromosomes during diplotene of meiosis.

Chromatid 

one of the components of a chromosome, formed in the nucleus during the interphase of the cell nucleus as a result of the chromosome’s duplication. In mitosis, each chromosome consists of two chromatids; after separating into the daughter nuclei, each chromatid becomes an independent chromosome. In meiosis, homologous chromosomes come together in pairs to make up a four-chromatid structure, or tetrad.

According to the single-chain chromosome model, each chromatid contains in cross section a single tightly coiled and condensed double-strand molecule of deoxyribonucleic acid (DNA). In the multichain chromosome model, it is assumed that each chromatid contains in cross section several DNA molecules, in which case various types of chromatids are distinguished, such as semichromatids and quarter-chromatids. Most experiments have confirmed the single-chain model.

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The appearance of a chromosome-type break, where two sister chromatids are broken at the same site, might be attributable to failure of HR to complete DSB repair, leading to the occurrence of a DSB in the other intact sister chromatid during the condensation of chromosome towards the M phase (Sonoda et al.
In addition, we found that, although sister chromatids enter meiosis in very close proximity to one another, Pds5 acts to inhibit synapsis between them, a good thing because, then, meiotic conditions support the necessary pairing of homologs," he added.
In this method, sister chromatids are differentially stained by immunostaining of mitotic chromosomes followed by treatment of cells with antibody against BrdUrd (Becton Dickson) and Alexa Fluor 488?
 
 
 
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