Basic semen analysis of the male patient and the fact that he had previously fathered a healthy child indicated that his fertility was not affected by his chromosomal translocation
, contrary to previous literature reports stating that male balanced translocations carriers are prone to sterility.
We know he has what is called a chromosomal translocation
- his chromosomes are all there, but they're arranged differently.
Janet Rowley revolutionized research in the field of cancer biology and the diagnosis and treatment of cancer through her discoveries of specific chromosomal translocations
in the leukemias and lymphomas.
The chromosomal translocation
t(15;17) generates the PML/RAR [alpha] fusion gene which plays an essential role in leukaemogenesis.
Mucosa-associated lymphoid tissue (MALT) lymphoma of the rectum with chromosomal translocation
of the t(11;18)(q21;q21) and an additional aberration of trisomy 3.
Chromosomal breaks are important in many diseases that stem from chromosomal translocation
, in which genes get switched around.
As a result of the t(11 ;22) chromosomal translocation
characterizing the Ewing family of tumors, the amino terminal portion of EWS, an RNA-binding protein of unknown function, is fused to the DNA-binding domain of one of the five members of the ets transcription factor family, most commonly ELI-1.
Once the chromosomal translocation
was discovered which disrupted the retinoic acid receptor, this explained the blunted response to ATRA.
Rowley is an American human geneticist and the first scientist to identify a chromosomal translocation
as the cause of leukemia and other cancers.
In comparing the blood cells of both twin sisters, these researchers identified a chromosomal translocation
generated what is known as the MLL-NRIP3 fusion leukemia gene.
He has chromosomal translocation
- his The reason for this turnaround is basic science: sunshine creates Vitamin D which is absorbed chromosomes are all there, but they're arranged differently.
He asserted that in blood cancers like leukaemia, DNA is rearranged during an event known as chromosomal translocation
, which results in a mutant protein that drives cancer progression.