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balanced translocation
(redirected from Chromosomal translocation)

    Also found in: Medical, Wikipedia 0.01 sec.
balanced translocation [′bal·ənst tranz·lō′kā·shən]
(genetics)
Positional change of one or more chromosome segments in cells or gametes without alteration of the normal diploid or haploid complement of genetic material.
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For example, the development of the drug imatinib (Gleevec)-one of the most successful targeted cancer therapies to date-stems directly from Rowley's work on the chromosomal translocation associated with CML.
JANET DAVIDSON AWARDED GRUBER GENETICS PRIZE by Biotech Business
Ledoux's 5-year-old son Colin was born with an unbalanced chromosomal translocation that has required treatment at that facility.
Day at Daytona a dream goal; Team will race for Children's Hospital ... by Telegram & Gazette (Worcester, MA)
The chromosomal translocation results in a fusion between RAR [alpha] and another gene whose product is 'PML', generating a fusion product PML-RAR [alpha] , a chimaeric oncoprotein that has been extensively studied over the last 10 years.
Acute promyelocytic leukaemia, all-trans-retinoic acid and arsenic by Wood, E.J. / Clinical Dermatology
 
 
 
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