balanced translocation

(redirected from Chromosomal translocation)
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balanced translocation

[′bal·ənst tranz·lō′kā·shən]
(genetics)
Positional change of one or more chromosome segments in cells or gametes without alteration of the normal diploid or haploid complement of genetic material.
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The balanced chromosomal translocation carriers have increased risk for pregnancy losses or having children with mental or physical abnormalities because of unbalanced segmental chromosomal losses and gains.
One prominent and unifying factor is the t(X;18)(p11;q11) chromosomal translocation, which is unique to synovial sarcoma and is identified in more than 95% of all cases.
Conclusions: The lung adenocarcinoma cell line OM exhibited multiple complex karyotypes, and chromosome 10 was frequently involved in chromosomal translocation, which may play key roles in tumorigenesis.
19] Recently, it has been discovered that MECs, irrespective of histological grade, are characterized by a recurrent chromosomal translocation t(11;19)(q21;p12) resulting in CRTC-MAML2 fusion in 40%-70% cases [20] [Figure 4].
It proves that phenotypically normal embryos originating from a chromosomal translocation carrier may be carrying chromosomal imbalances.
In 95% of cases, the cause of DS is chromosomal aneuploidy, Trisomy 21, but rare cases of DS can arise from either chromosomal translocation or from mosaicism.
T (1;14) is an infrequently occurring recurrent chromosomal translocation that has been described in literature to be associated with haematological malignancies.
Little Hugh Murphy, of Sheldon, is thought to be the only person in the world with chromosomal translocation.
Acute promyelocytic leukemia with the pseudo-Chediak-Higashi anomaly and molecular documentation of t(15;17) chromosomal translocation.
For example," said Kadoch, "a type of mutation called a chromosomal translocation in the gene encoding one of these newly identified subunits, SS18, is known to be the hallmark of a cancer called synovial sarcoma.
In blood cancers such as leukemia, DNA is rearranged during an event known as chromosomal translocation, which results in a mutant protein that drives cancer progression.
Bruce Ledoux created Guardian Angel Motorsports after his son, Colin, was born with an unbalanced chromosomal translocation.

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