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chromosome painting

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chromosome painting [′krō·mə‚sōm ‚pānt·iŋ]
(genetics)
Rendering a specific chromosome or chromosome segment distinguishable by deoxyribonucleic acid hybridization with a pool of many fluorescence-labeled DNA fragments derived from the full length of a chromosome or segment.


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Multicolor chromosome painting in diagnostic and research applications.
To delineate the nature of the complex translocations, the FISH technique using whole chromosome painting probes (wcp) for chromosomes 9 (wcp9, SO/DAPI [spectrum orange/4',6-diamidino-2-phenylindole dihydrochloride], Vysis), 22 (wcp22, SO/DAPI, Vysis), and 11 (wcp11, fluorescein isothiocyanate/propidium iodide, American Laboratory Technology, Inc) was applied.
The main advantage of chromosome painting is its rapid overall evaluation of the extent and character of genomic conservation among distantly related species, such as pig and cattle.
 
 
 
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