cyclosporin A

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Related to Ciclosporin: tacrolimus

cyclosporin A

[¦sī·klə‚spȯr·ən ′ā]
(biochemistry)
A cyclic peptide produced by some fungi. It inactivates helper T cells, making it useful as an immunosuppressive drug, especially in the prevention of graft rejection in transplantation surgery.
References in periodicals archive ?
The final step is short courses of systemic treatments such as azathioprine, methotrexate, ciclosporin, retinoids and oral corticosteroids.
This positive response was evident not only in dogs that had never received treatment before but also in dogs resistant or intolerant to ciclosporin or corticosteroids, and dogs with severe pruritus, two groups representing populations with high unmet medical need".
Despite its teratogenicity and the high incidence of symptomatic mucocutaneous side-effects, it was moderately effective as monotherapy at doses of 1 mg/kg/d (75 mg/d) compared with placebo, but was less effective than ciclosporin.
Psoriasis is a chronic autoimmune disorder and patients with moderate-to-severe disease may be treated with a variety of systemic therapies such as methotrexate, ciclosporin, retinoids, corticosteroids and/or phototherapy (e.
A randomised, double blind, placebo controlled, multicentre trial of combination therapy with methotrexate plus ciclosporin in patients with active psoriatic arthritis.
Ciclosporin - oral solution 100 mg / ml - 50 ml - 120 pieces;
If scleritis develops oral steroids and immunosuppressive therapy such as ciclosporin is often necessary.
Simultaneous on-line extraction and analysis of sirolimus (rapamycin) and ciclosporin in blood by liquid chromatography-electrospray mass spectrometry.
A positive response to masitinib was evident for treatment-naove dogs, dogs resistant to ciclosporin and/or corticosteroids, and dogs with severe pruritus, the latter two groups representing populations with high unmet medical need.