Ciechanover, Aaron


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Ciechanover, Aaron,

1947–, Israeli biochemist, M.D. Hebrew Univ.–Hadassah Medical School, Jerusalem, 1974; D.Sc. Technion (Israel Institute of Technology), Haifa, 1982. He has been on the faculty at the Technion since 1986. Ciechanover received the 2004 Nobel Prize in Chemistry with Avram HershkoHershko, Avram,
1937–, Israeli biochemist, M.D. Hebrew Univ.–Hadassah Medical School, Jerusalem, 1965, Ph.D. 1969. Hershko has been a professor at the Rappaport Faculty of Medicine at the Technion (Israel Institute of Technology), Haifa, since 1972.
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 and Irwin RoseRose, Irwin,
1926–2015, American biochemist, b. Brooklyn, N.Y., Ph.D. Univ. of Chicago, 1952. Rose was on the faculty of Yale Medical School from 1954 to 1963 and a senior member of the Fox Chase Cancer Center in Philadelphia from 1963 until 1995.
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 for the discovery of the mechanism underlying protein degradation. Their work resulted in a molecular-level understanding of how cells control processes such as DNA repair, cell division, and immune functions by using a regulatory tag called ubiquitin to mark selected proteins for degradation. This knowledge has helped in the fight against diseases—for example, cystic fibrosis and cervical cancer—that result when the degradation is not carried out properly.