complement (redirected from Classical complement pathway)

complement: see immunity.

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complement

In physiology, a complex system of at least 20 proteins (complement components) in normal blood serum. The binding of one component to an antigen-antibody complex begins a chemical chain reaction important in many immunological processes, including breakdown of foreign and infected cells, ingestion of foreign particles and cell debris, and inflammation of surrounding tissue. Complement components and antibodies are the substances in human serum responsible for killing bacteria.

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complement

The number derived by subtracting a number from a base number. For example, the tens complement of 8 is 2. In set theory, complement refers to all the objects in one set that are not in another set.

Complements are used in digital circuits, because it's faster to subtract by adding complements than by performing true subtraction. The binary complement of a number is created by reversing all bits and adding 1. The carry from the high-order position is eliminated. The following example subtracts 5 from 8.

     Decimal    Binary    Complement
      8          1000      1000
     -5         -0101     +1011
     __         _____     _____
      3          0011      0011

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complement

1. the officers and crew needed to man a ship

2. Maths the angle that when added to a specified angle produces a right angle

3. Logic Maths the class of all things, or of all members of a given universe of discourse, that are not members of a given set

4. Music the inverted form of an interval that, when added to the interval, completes the octave

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Complement

A group of proteins in the blood and body fluids that play an important role in humoral immunity and the generation of inflammation. When activated by antigen-antibody complexes, or by other agents such as proteolytic enzymes (for example, plasmin), complement kills bacteria and other microorganisms. In addition, complement activation results in the release of peptides that enhance vascular permeability, release histamine, and attract white blood cells (chemotaxis). The binding of complement to target cells also enhances their phagocytosis by white blood cells. The most important step in complement system function is the activation of the third component of complement (C3), which is the most abundant of these proteins in the blood.

Genetic deficiencies of certain complement subcomponents have been found in humans, rabbits, guinea pigs, and mice. Certain deficiencies lead to immune-complex diseases, such as systemic lupus erythematosus; other deficiencies result in increased susceptibility to bacterial infections, particularly those of the genus Neisseria (for example, gonorrhea and meningococcal meningitis), and hereditary angioneurotic edema. See Complement-fixation test, Immunity

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(logic)

complement - The other value or values in the set of possible values. See logical complement, bitwise complement, set complement.