Light-driven shedding is mediated by arrestin and clathrin
(Sacunas et al.
Furthermore, the accumulation of phosphorylated a-synuclein was observed in neuronal cell bodies in an AP-2 (a clathrin
adaptor protein) subunit knockdown, mimicking synucleinopathy ([alpha]-synuclein-mediated neurodegenerative disorder).
SNP Top BLASTx hit Accession 35,850 Clathrin
heavy chain [Penaeus monodon] AJM87267.
A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin
The constitutively expressed gene clathrin
adapter complex (CAC) was used as a positive control (Exposito-Rodriguez et al.
lt;B A Clathrin
Cage which takes takes molecules around in a cell Maria Voigt
The complex now enables clathrin
to associate with the receptor and to build a clathrin
coated pit in which the receptor is internalized via endocytosis (Claing et al.
Contrarily, CD1a does not interact with AP-2 and is internalized using clathrin
and dynamin-independent pathways .
Schein came to the cagelike molecules because he was curious about clathrin
, a protein that assembles itself in cages.
is involved in moving resources inside and outside cells, and in that process it forms only a handful number of shapes.
It constitutively cycles through clathrin
vesicles and recycling endosomes in a pathway that is not dependent on cAMP signaling in endothelial cells.
coat is needed for invagination of the cell membrane.