Clinical immunology

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Clinical immunology

A branch of clinical pathology concerned with the role of the immune defense system in disease. The subject encompasses diseases where a malfunction of the immune system itself is the basic cause, together with diseases where some external agent is the initiating factor but an excessive response by the immune system produces the actual tissue damage. It also extends to the monitoring of the normal immune response in infectious diseases and to the use of immunological techniques in disease diagnosis. See Allergy, Autoimmunity, Hypersensitivity, Immunological deficiency

Many features of the immune system make it prone to shift from protecting the body to damaging it. This complex system not only must distinguish between the body's own cells and a foreign invader but must also recognize and eliminate the body's own cells if they are damaged or infected with a virus. The recognition receptors used to make this fine distinction between “self” and “not self” are not encoded in the genes. Rather, they are assembled following random rearrangement of information carried in small gene segments. During their development, immune system cells are subjected to a selective process, those bearing potentially useful receptors being preserved while those bearing dangerous, self-reactive receptors are eliminated. This process is closely balanced, and some potentially self-reactive cells often persist. See Cellular immunology

There are several approaches to suppressing excessive immune reactivity. Desensitization, or modifying the nature of the response by injecting small amounts of the foreign antigen, is sometimes used to treat allergic states. In contrast, there are few therapies for enhancing immune responses. Bone marrow transplantation is used to restore the immune system in some immunodeficiency diseases. Passive transfer of preformed antibody protects against some infections, and transfusion of immunoglobulin is used to treat immunoglobulin deficiencies. However, vaccination or immunization is one of the most effective of all medical procedures. See Immunosuppression

References in periodicals archive ?
Cytokines present in breast milk may decrease an infant's risk of developing asthma, according to a study published in the October 2003 Journal of Allergy and Clinical Immunology (JACI).
EAACI - The European Academy of Allergy and Clinical Immunology is a non-profit organisation active in the field of allergic and immunologic diseases such as asthma, rhinitis, eczema, occupational allergy, food and drug allergy and anaphylaxis.
Children growing up on farms may have less of a chance of developing allergies and asthma, according to a study published in the September 2003 Journal of Allergy and Clinical Immunology.
The European Academy of Allergology and Clinical Immunology, EAACI, is a scientific society promoting research and education in the allergy and clinical immunology.
CONTACT: Laura Kalies of Federation of Clinical Immunology Societies, +1-414-224-8095, Fax +1-414-272-6070
Medical Director of the Parker Hughes Center for Clinical Immunology.
The World Allergy Congress is jointly sponsored by the World Allergy Organization (WAO) and the European Academy of Allergy and Clinical Immunology (EAACI), and is being held for the first time in Germany.
MILWAUKEE -- The Federation of Clinical Immunology Societies (FOCIS) announces the formation of a designation and grant program to assist academic institutions in establishing comprehensive FOCIS Centers to promote multidisciplinary scientific and clinical innovation, education, and advocacy in their local communities.
Calabrese currently heads Cleveland Clinic's Section of Clinical Immunology and manages its Clinical Immunology Clinic.
European Academy of Allergy and Clinical Immunology (EAACI), 2014.
Contract notice: Delivery of reagents, calibrators, control materials and additional materials necessary for the execution of specific protein assays along with the lease of immunochemical analyzer and refrigeration equipment for the department of laboratory diagnostics and clinical immunology branch of the developmental age spdsk street.
According to a study published in the Journal of Allergy and Clinical Immunology, children with winter-related atopic dermatitis may benefit from vitamin D supplementation.

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