agonist

(redirected from Co-agonist)
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agonist

[′ag·ə‚nist]
(biochemistry)
A chemical substance that can combine with a cell receptor and cause a reaction or create an active site.
(physiology)
A contracting muscle that is resisted or counteracted by another muscle, called an antagonist, with which it is paired.
References in periodicals archive ?
This suggests that at low concentrations, EVP-6124 acts as a co-agonist and sensitizes the alpha-7 receptor to its natural response to ACh, but does not desensitize the receptor.
The lead compound in EnVivo's alpha-7 agonist program, EVP-6124, is a selective, potent, brain penetrant oral compound that offers a novel mechanism of action - it enhances synaptic transmission in the brain and acts as a co-agonist in combination with Acetylcholine (ACh) to enhance cognition.
This novel PPAR co-agonist is one of an emerging new class of insulin sensitizers and lipid regulators with enhanced potential in the treatment of type 2 diabetes (NIDDM), which affects the health of over 15 million Americans, and cardiovascular disease, the leading cause of death in industrialized countries," said Andres Negro-Vilar, M.