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5% of the entire study cohort]); in the other 5 patients SPS coexisted with other well known hereditary coagulation defects, which is similar to previous studies that reported that 83% (14) and 33% (15) of patients with SPS presented with additional congenital prothrombotic conditions.
In about 50% of patients that present with venous thrombosis a hereditary or acquired coagulation defect, or a platelet disorder is present (1).
The most common genetic blood coagulation defect was FVL mutation.
Specifically, patients with coagulation defects have an increased propensity to clot in either the arteries or the venous system or both.
To our knowledge, this study represents the largest series of patients with ischemic colitis examined for coagulation defects in the United States.
The presence of high-risk situations, such as malignancy, pregnancy, use of estrogens, and surgery, increase the chances of hypercoagulability in those with either inherited or acquired coagulation defects.