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1. the death of one or more cells in the body, usually within a localized area, as from an interruption of the blood supply to that part
2. death of plant tissue due to disease, frost, etc.



the death within the living organism of individual organs or their component tissues or cells.

A necrosis is classified according to the pathological condition that causes it. Thus, frostbite and burns can cause traumatic necrosis; neurotropic necrosis arises with syringomyelia and the nervous form of leprosy; infarcts and gangrene are associated with circulatory, or ischemic, necrosis; caseous necroses occurring in tuberculosis and syphilis are forms of septic necrosis; and fibrinoid necrosis associated with allergic diseases is a type of allergic necrosis.

Necrosis is accompanied by characteristic changes in the cell and in the intercellular substances. The nucleus shrinks and coagulates, a process known as pycnosis, and the cytoplasm breaks up into clumps. The cell eventually lyses, that is, it degenerates and dissolves. The lysis is due to the activation of the lysosomal hydrolytic enzymes, such as ribonuclease, deoxyribonuclease, and acid phosphatase. The activation of the lysosomes occurs as a result of an increase in the permeability of the cell membranes, changes in the osmotic equilibrium, and acidosis—an abnormal increase in the intracellular hydrogen-ion concentration. Fibrinoid changes appear in the connective tissue, and nerve fibers become fragmented and disintegrate into clumps.

The clinical and morphological manifestations and further consequences of necrosis depend on the localization and distribution of the necrosis and on the mechanisms and conditions of origin. The following types of advanced necrotic conditions can develop: dry necrosis, such as Zenker’s degeneration of infected muscles; colliquative, or liquefactive, necrosis, which occurs for example, when a focus of softening arises in the brain in response to cerebral hemorrhage; gangrene; and bed sores. Necrotic tissue tears away; then, either connective tissue grows through it or the necrotic tissue undergoes autolytic or purulent liquefaction. Finally, the necrotic tissue becomes encapsulated and petrified.

The two most serious consequences of necrosis are a loss of function owing to the death of the structural elements of the necrotic tissues or organs and poisoning caused by the actual presence of a necrotic focus and by the inflammation that arises in response to this presence.



Death of a cell or group of cells as a result of injury, disease, or other pathologic state.
References in periodicals archive ?
have been isolated from different organs without associated pathologic changes other than coagulative necrosis of the spleen (6) and a testicular abscess (9).
The last three patients in the series--who received the highest concentrated dose of ultrasound waves--showed complete coagulative necrosis in 75% of the targeted area.
The technology, known as magnetic resonance-guided focused ultrasound (MRgFUS), induces coagulative necrosis of fibroids through thermoablation.
Hwang concluded that using China Medical HIFU therapy system to treat pancreas is feasible and safe, and lesion formation of coagulative necrosis and apoptosis can be observed following proper treatment protocol.
5,6] Previous reports on the histopathological findings after HIFU have noted coagulative necrosis with sharply defined margins[sup.
Dense fibrous tissue was present with a large area of coagulative necrosis with areas of haemorrhage.
Several authors have established that during the preulcerative stage and early in the ulcerative stage, the coagulative necrosis forms a nidus where calcifications and AFB colonies are easily visualized (8,9,12,17).