Colchicum alkaloid definition of Colchicum alkaloid in the Free Online Encyclopedia.

colchicine (kŏl`chəsēn'), alkaloid extracted from plants of the genus Colchicum and especially from the corms of the autumn crocus, Colchicum autumnale (see meadow saffron meadow saffron or autumn crocus, perennial garden ornamental (Colchicum autumnale) of the family Liliaceae ( lily family). Native to Europe and N Africa, it has escaped from gardens to meadows and fields in some parts of the United States.
..... Click the link for more information. ). The metabolic effect of colchicine is not known, but it is thought that it may decrease production of lactic acid and prevent accumulation of uric acid crystals in the body, making it useful in the treatment of gout. Colchicine and derivatives such as demecolcine inhibit mitosis interphase the chromosomes are dispersed in the nucleus and appear as a network of long, thin threads or filaments, called the chromatin. At some point before prophase begins, the chromosomes replicate themselves to form pairs of identical sister chromosomes, or chromatids; the
..... Click the link for more information. , or cell division. As a mitotic poison, it inhibits rapidly proliferating cells and has been used in cancer therapy and as an immunosuppressive drug immunosuppressive drug, any of a variety of substances used to prevent production of antibodies . They are commonly used to prevent rejection by a recipient's body of an organ transplanted from a donor.
..... Click the link for more information. . Colchicine has also been used to visualize chromosomes photomicrographically and to induce mutations experimentally.

colchicine (redirected from Colchicum alkaloid)

colchicine
(redirected from Colchicum alkaloid)