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cold agglutinin
(redirected from Cold agglutinin disease)

   Also found in: Dictionary/thesaurus, Medical, Wikipedia 0.01 sec.
cold agglutinin [′kōld ə′glüt·ən·ən]
(immunology)
A nonspecific panagglutinin found in many normal human serums which produce maximum clumping of erythrocytes at 4°C and none at 37°C.


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Cold agglutinin disease is actually a group of disorders that are characterized by antierythrocyte autoantibodies that bind red blood cells at cold temperatures (
Cold Agglutinin Disease is a very, rare, immune mediated condition, in which components of blood agglutinate in the vessels, causing thrombus formation with subsequent loss of blood supply.
It is caused by drugs inducing autoimmune RBC antibodies (autoimmune mnechanism-[alpha]-methyldopa type) (1) Steroids, splenectomy, and plasmapheresis are generally unsuccessful in the treatment of cold agglutinin disease.
 
 
 
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