cold agglutinin

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Related to Cold agglutinin disease: cold antibody

cold agglutinin

[′kōld ə′glüt·ən·ən]
(immunology)
A nonspecific panagglutinin found in many normal human serums which produce maximum clumping of erythrocytes at 4°C and none at 37°C.
References in periodicals archive ?
TNT009 is currently in clinical development for the treatment of Cold Agglutinin Disease (CAD), a rare disease in hematology.
Results from ex-vivo studies using plasma samples from patients with a type of AIHA, known as cold agglutinin disease (CAD), showed that red blood cells exposed to patient samples contained high levels of Complement proteins deposited on the cell surface.
Thrombocytopenia and even pancytopenia may be present, as well as a cold agglutinin disease characterized by an autoimmune hemolytic anemia.