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Localized tissue anemia as a result of obstruction of the blood supply or to vasoconstriction.



a local deficiency of blood; insufficient blood in an organ or tissue because of the narrowing or complete occlusion of the lumen of an afferent artery.

Transitory ischemia (like hyperemia) may result from physiological regulation of the blood supply, such as in reflex spasm of an artery caused by a mental factor (fright); the influence of pain, cold, chemical substances (epinephrine, ergotin), and biological stimuli (bacteria, toxins); the obstruction of an artery by a thrombus or embolus; constriction of the lumen of a blood vessel in connection with an atherosclerotic or inflammatory process in the wall; or compression of an artery by a tumor, scar, or foreign body. The aftereffects of ischemia depend on the degree of disruption of the blood flow, the rate of development and duration of the ischemia, the sensitivity of the tissue to oxygen deficiency, and the general condition of the body. Ischemia may end in complete restoration of the structure and function of the affected organ or tissue, but it also may lead to necrosis (infarct). The central nervous system and heart muscle are particularly sensitive to ischemia.


References in periodicals archive ?
The findings that a selected number of older donor grafts exposed to the same length of cold ischemia display more profound ischemic/preservation injury as manifested by increased DNF and poorer initial graft function indicate that specific biochemical/ enzymatic circuits are affected beyond recovery.
In the current study, we observed that nephrometry score applied to OPN series under cold ischemia was not significantly associated with perioperative outcomes, especially ischemic time, complications and postoperative renal functional preservation among a consecutive case series of Korean men.
24] If the same renal functional volume is lost, we should use cold ischemia in PN.
We found that by using cold ischemia, we had spare time during surgery to allow for more delicate procedures, such as renal reconstruction or repair of the collecting system.
OPN under cold ischemia was safely performed regardless of tumour complexity.
The link between HLA matching and cold ischemia and cadaveric kidney survival has been noted by other investigators.
In univariable analyses, categorized cold ischemia time (p = 0.
In multivariable analyses, cold ischemia time (p = 0.
For example, cold ischemia times might be maximally reduced and the number of HLA mismatches might be minimized.
Since UNOS established the national kidney-sharing program in 1987, many have argued that the resultant increased duration of cold ischemia would offset the benefit of shipping kidneys to HLA-matched patients.
Nonetheless, the mean duration of cold ischemia was comparable-23 hours for patients given HLA-matched kidneys and 22 hours for patients who received HLA-mismatched kidneys-and well within the cut-off point set by the UCSF investigators.
Delayed graft function appeared to be affected more by cold ischemia time than by the number of HLA mismatches.