Ischemia

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ischemia

[i′skē·mē·ə]
(medicine)
Localized tissue anemia as a result of obstruction of the blood supply or to vasoconstriction.

Ischemia

 

a local deficiency of blood; insufficient blood in an organ or tissue because of the narrowing or complete occlusion of the lumen of an afferent artery.

Transitory ischemia (like hyperemia) may result from physiological regulation of the blood supply, such as in reflex spasm of an artery caused by a mental factor (fright); the influence of pain, cold, chemical substances (epinephrine, ergotin), and biological stimuli (bacteria, toxins); the obstruction of an artery by a thrombus or embolus; constriction of the lumen of a blood vessel in connection with an atherosclerotic or inflammatory process in the wall; or compression of an artery by a tumor, scar, or foreign body. The aftereffects of ischemia depend on the degree of disruption of the blood flow, the rate of development and duration of the ischemia, the sensitivity of the tissue to oxygen deficiency, and the general condition of the body. Ischemia may end in complete restoration of the structure and function of the affected organ or tissue, but it also may lead to necrosis (infarct). The central nervous system and heart muscle are particularly sensitive to ischemia.

N. R. PALEEV

References in periodicals archive ?
They set up an in vitro experimental model of freshly isolated rat hepatocytes mimicking hepatocyte reoxygenation injury after the cold ischemia phase of liver graft preservation.
However, the best model for patients without hepatitis C included donor age, cold ischemia time, gender, race/ethnicity, recipient age, BMI, MELD score, status at time of transplantation, diabetes mellitus, cause of liver disease, and serum albumin.
In general, primary nonfunction (PNF) and delayed nonfunction (DNF) of the graft were best correlated with the age of the donor, mechanism of death, the development of significant hemodynamic instability requiring treatment with multiple vasopressors, and the length of cold ischemia time.
sup][17],[18] It usually refers to donor hearts with characteristics extending beyond the standard criteria, such as donor age >50 years, cold ischemia time >6 h, donor/recipient weight ratio <0 .
DNA extracted from FFPE tissue that was subjected to a cold ischemia time of 1 hour displayed reduced fluorescent in situ hybridization (FISH) signals, (5) although a cold ischemia time of 24 hours did not alter PCR amplification success rates (data not shown).
The mean values for duration of hospitalization after the operation and cold ischemia time were 12.
Another trend for ECD kidneys was toward short cold ischemia times of less than 12 hours.
To minimize cold ischemia time, islets are infused into the portal vein right away or within a maximum of 12 hours from the time they are harvested, Only high-quality islets without xenoproteins are used, and more islet cells are transplanted than have been used in previous procedures, Dr.
Toledo explained that using the model for rat kidney preservation is more sensitive to cold ischemia (lack of blood) than for human kidneys as far as preservation time is concerned.
Not surprisingly, we have also learned that cold ischemia time is important to the viability of some antigens.
In this study, we applied the nephrometry score to patients who underwent open partial nephrectomy (OPN) with cold ischemia and we confirm the usefulness of the nephrometry score to confirm postoperative outcomes.
These include kidneys from patients over age 55, kidneys from patients with a history of hypertension or diabetes mellitus, and kidneys subjected to cold ischemia for greater than 36 hours--all of which are associated with increased graft failure rates and decreased survival.