collagenase

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Related to Collagenases: Interstitial collagenase

collagenase

[′kä·lə·jə‚nās]
(biochemistry)
Any proteinase that decomposes collagen and gelatin.
References in periodicals archive ?
Our study indicated that SalA was a selective inhibitor on gelatinase than collagenase in vitro and a specific inhibitor on MMP-9 than MMP-2 in vivo.
Collagenase ointment is a sterile enzymatic debriding ointment which contains 250 collagenase units per gram of white petrolatum USP.
In double-blind studies of patients with advanced Dupuytren's, significantly greater proportions of patients treated with collagenase Clostridium had almost a complete reduction in contractures, compared with those who received placebo.
The Food and Drug Administration's Arthritis Advisory Committee voted 12-0 that the treatment, collagenase clostridium histolyticum, should be approved for treating advanced Dupuytren's, based on the available safety and efficacy data.
In situ hybridization studies of stromelysin and collagenase messenger RNA expression in rheumatoid synovium.
Studies analyzing wound fluid show it to be rich in growth factors, collagenase, enzymes and other cells crucial to healing.
Follow-up tests showed that the tetracycline disarmed the collagenase made by certain immune system cells that contribute to inflammation, but other antibiotics had no effect.
1 Collagenase clostridium histolyticum is the first injectable treatment to be approved in the EU for the treatment of Dupuytren's contracture.
Immunohistochemically distribution of type IV collagenase in normal, benign and malignant breast tissue.
Rocheos Liberase Enzymes are mixtures of collagenases and neutral protease enzymes, formulated for efficient dissociation of tissue from a wide variety of sources.
In addition to degrading numerous extracellular-matrix components, MMP3 can activate gelatinase B and the collagenases and release several cell surface molecules, including E-cadherin, a known contributor to cancer development (6).
Zinc deficiency reduces the synthesis and activity of alkaline phosphatase in rats and the activity of collagenase in chicks.