colon cancer

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colon cancer,

cancer of any part of the colon (often called the large intestineintestine,
muscular hoselike portion of the gastrointestinal tract extending from the lower end of the stomach (pylorus) to the anal opening. In humans this fairly narrow (about 1 in./2.
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). Colon cancer is the second most common cancer diagnosed in the United States. Epidemiological evidence has shown that a diet high in fat and low in fruits, vegetables, and fiber contributes to the development of the disease. Smoking is also a factor in some types of colon cancer. Statistically, a family history of colon cancer or cancer of the female reproductive organs, a history of colon polyps, or a history of ulcerative colitis puts one at a greater risk of developing colon cancer. Colon cancer is most common in people over age 50.

Several genes that signal a hereditary predisposition to colon cancer have been identified. For example, mutations in either of two genes, MSH2 and MLH1, can predispose a person to hereditary nonpolyposis colorectal cancer (HNPCC). People in HNPCC families can undergo blood tests that can tell them whether they have an affected gene. With the information obtained from such screening, an appropriate course of preventive measures and follow-up tests can be initiated (see genetic testinggenetic testing,
medical screening for genetic disorders, by examining either a person's DNA directly or a person's biochemistry or chromosomes for indirect evidence. Testing may be done to identify a genetic disorder a person has, whether the disorder is already evident or not,
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A sudden change in bowel habits or blood in the feces (often detectable only in a laboratory) may be the first symptoms of colon cancer. In the early stages of the disease there may be no obvious symptoms. Diagnosis is made by physical examination of the rectum and a laboratory examination of blood for carcinoembryonic antigen (CEA), a tumor marker produced by colon cancers. These may be followed by an endoscopic examination of the colon with a sigmoidoscope (to examine the rectum and the adjoining sigmoid colon) or colonoscope (to examine the entire colon). A biopsybiopsy
, examination of cells or tissues removed from a living organism. Excised material may be studied in order to diagnose disease or to confirm findings of normality. Preparatory techniques depend on the nature of the tissue and the kind of study intended.
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 of any suspicious tissue, such as a polyp or a flat or depressed lesion, is then examined in a laboratory to determine if cancerous changes are present. If cancer is found, the patient is evaluated to determine the extent of the primary tumor and whether the disease has spread throughout the body.


Treatment depends upon the stage of the cancer. The initial treatment is usually local excision of the tumor or excision of a larger part of the colon followed by the joining of the two adjacent ends, a procedure referred to as end-to-end anastomosis. In some cases a colostomy (an opening that allows waste to be expelled through an opening in the abdomen rather than through the anus) is created either temporarily, to allow healing, or permanently, if significant portions of the colon have had to be removed. If the disease is advanced, radiation therapy, chemotherapy, or biological therapies (therapies that stimulate the body's own immune defenses against the disease) may be used in addition to surgery.


See publications of the National Cancer Institute, the American Cancer Society, and the United Ostomy Association.

References in periodicals archive ?
A new fecal-DNA test, by contrast, looks for human-genetic material that contains certain abnormalities associated with colorectal cancer.
FAMILY HISTORY: Less than 1 in 10 cases of colorectal cancer are due to an inherited gene defect.
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The 60 colorectal cancer advocates from around the country are on Capitol Hill as part of Fight Colorectal Cancer's Call-on Congress.
1070, Removing Barriers to Colorectal Cancer Screening Act, in 2013 to remove an error in Medicare law charging seniors a co-pay when they undergo a screening colonoscopy and a polyp is removed during the procedure.
Today, even among those with health insurance, screening rates for colorectal cancer are much too low - less than half of those who should be screened get screened," said Nancy Roach, Chair of Fight Colorectal Cancer's Board of Directors.
A review of the Colorectal Cancer products under development by companies and universities/research institutes based on information derived from company and industry-specific sources
The more recent study may have found no colorectal cancer because people at risk of the other cancers didn't live long enough to get it, Godwin says.
This critical legislation will ensure that even in tight fiscal times, funding for life-saving federal colorectal cancer research programs can be sustained.
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Six years after the genetic mutations that predispose some people to colorectal cancer were first identified, researchers have uncovered another, more unusual defect that can double a person's risk.