combinatorial chemistry

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combinatorial chemistry

[kəm‚bīn·ə¦tȯr·ē·əl ′kem·ə·strē]
(organic chemistry)
A method for reacting a small number of chemicals to produce simultaneously a very large number of compounds, called libraries, which are screened to identify useful products such as drug candidates.
References in periodicals archive ?
Additionally, CombiChem has established two 50%-owned joint ventures.
Todd has also held senior level finance positions at CombiChem, Inc.
Throughout his career at Forward, Fleming has served as acting president of Triangle Pharmaceuticals (NASDAQ:VIRS), Actigen (now Corixa (NASDAQ:CRXA)), GenQuest (now Corixa (NASDAQ:CRXA)) and CombiChem (now DuPont Pharmaceuticals (NYSE:DD)).
Peter Myers held senior scientific leadership positions at Glaxo Research Institute, Onyx Pharmaceuticals, Deltagen Research Laboratories (formerly BMS/DuPont Pharmaceuticals Research Laboratories), CombiChem Inc.
Keywords in this release: functional genomics, encoded proteins, therapeutic targets, sequence homology, neuropsychiatry, cardiovascular medicine, endocrinology, oncology, combinatorial chemistry, combichem, compound library, new molecular entities, NME, high-throughput screening, HTS, accelerator mass spectrometry, microdosing, animal/ex vivo models, human drug absorption, HDA, Enterion capsule, pharmacokinetic data, PK data, absorption, distribution, metabolism and excretion data, ADME data.
McCracken has also served in senior executive roles in privately financed start-ups to established public companies such as Allergan, CombiChem (merged into DuPont Pharma), and GenStar Therapeutics (merged into Corautus).
It has quickly become the preferred high-performance choice for customers performing demanding research in drug development, metabonomics, discovery of peptide biomarkers, combichem analysis, etc.
Suto held senior management positions at Deltagen Research Laboratories, DuPont Pharmaceuticals, and CombiChem, Inc.
He also has been the Chairman of Vitesse Semiconductor (Nasdaq:VTSS), Redback Networks (Nasdaq:RBAK), Plumtree Software (Nasdaq:PLUM), Verisity Design (Nasdaq:VRST), Cypress Semiconductor (NYSE:CY), Microchip Tech (Nasdaq:MCHP), Combichem (acquired by Dupont).
The ADME models can also be used with the CombiChem add-on module, enabling scientists to design, construct, and refine compound libraries directly within the Microsoft Excel environment prior to laboratory synthesis or biological screening.
Myers' scientific leadership, CombiChem established eight major partnerships with companies such as Roche, Sumitomo, Ono and Novartis and achieved significant financial milestones in several of these collaborations.
Kassel served as senior director of DuPont Pharmaceuticals Research Labs and Director of analytical chemistry at CombiChem, Inc.