competitive inhibition

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competitive inhibition

[kəm′ped·əd·iv ‚in·ə′bish·ən]
(biochemistry)
Enzyme inhibition in which the inhibitor competes with the natural substrate for the active site of the enzyme; may be overcome by increasing substrate concentration.
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The first property is that an uncompetitive inhibitor as a target conjugate is preferred over a competitive inhibitor because uncompetitive inhibitors are rare in nature and should be less susceptible to interferences from drugs and naturally occurring substances, which frequently are competitive inhibitors of enzymes.
It's a very straightforward competitive inhibitor of the enzyme,' Goldman says.
The coactivator and growth promoting functions of AKR1C3 were inhibited by a novel AKR1C3-selective, competitive inhibitor developed by GTx.
Enzyme kinetic studies showed that the MA was not only a competitive inhibitor of CYP3A4 in humans, but also a competitive inhibitor of CYP2C11 and 3A2 in rats, with [K.
Carnosine has been shown to act as a competitive inhibitor of the non-enzymatic glycosylation of proteins," Babizhayev and colleague A.
Perchlorate is a competitive inhibitor of the sodium iodide symporter, the thyroid cell-surface protein responsible for transporting iodide from the plasma into the thyroid.
Alpha methyl ornithine, a potent competitive inhibitor of ornithine decarboxylase blocks proliferation of rat hepatoma cells in culture.

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