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competitive inhibition |
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competitive inhibition [kəm′ped·əd·iv ‚in·ə′bish·ən] (biochemistry) Enzyme inhibition in which the inhibitor competes with the natural substrate for the active site of the enzyme; may be overcome by increasing substrate concentration. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Originally, protease inhibitors were derived from the peptide substrates of the proteases, which led to the development of peptidomimetic competitive inhibitors. Currently available anti-estrogens, such as tamoxifen, are competitive inhibitors that bind to the ligand binding sites of estrogen receptors (ER). Currently available anti-estrogens, such as tamoxifen, are competitive inhibitors that bind to the ligand binding sites of estrogen receptors (ER). |
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