competitive inhibition

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competitive inhibition

[kəm′ped·əd·iv ‚in·ə′bish·ən]
(biochemistry)
Enzyme inhibition in which the inhibitor competes with the natural substrate for the active site of the enzyme; may be overcome by increasing substrate concentration.
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Hirsutism stemming from hyperandrogenism often can be lessened by competitive inhibitors of the androgen receptor.
While the previous generation of p38 MAPK inhibitors suffered from side effects such as liver transaminase elevations, the newer inhibitors are more selective at targeting p38 and include non-ATP competitive inhibitors directed against the conformation epitope.

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