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complement cascade

   Also found in: Dictionary/thesaurus, Medical, Legal, Wikipedia 0.01 sec.
complement cascade [′käm·plə·mənt kas′kād]
(immunology)
The sequential activation of complement proteins resulting in lysis of a target cell.


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The complement cascade has been implicated in the destruction of red blood cells, or hemolysis, characteristic of PNH, as PNH blood cells are deficient in natural inhibitors of the complement cascade.
Activation of the terminal complex C5b-9 in the complement cascade can promote demyelination and oligodendrocyte death.
Abstract One hundred and seventy-eight ethanolic plant extracts from the pharmacopoeia of the Tacana, an ethnic group from Bolivia, were screened for immunomodulatory activity using complement cascade inhibition and ADP-induced platelet aggregation inhibition assays.
 
 
 
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