complement cascade

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complement cascade

[′käm·plə·mənt kas′kād]
(immunology)
The sequential activation of complement proteins resulting in lysis of a target cell.
References in periodicals archive ?
Tender for construction of complement system Water and Sanitation Bsicoen Pojopn Village, Esquipulas Palo Gordo.
In PNH, the complement system mistakenly destroys blood cells due to the absence of a GPI-anchored proteins that would normally protect the blood cell from the activity of the complement system.
The complement system is composed of more than 30 distinct humoral and cell surface proteins (Volanakis, 1998).
DI FRANCESCO argues that big data is part of a complement system consisting of the data itself, software, and networks.
Each evaluation has come to the same conclusion, Eculizumab does the job of controlling an aHUS patient's compromised complement system and without it their own immune system would proceed to destroy major organs resulting in death or a much depleted quality of life.
The first two parts discuss effector mechanisms and their mediating cells including antibody-dependent cytotoxicity, the complement system, phagocytosis, natural killer and B cells.
Under the terms of the agreement Annexon will provide antibodies against specific components of the complement system and Antitope will use its Composite Human Antibody technology to generate a series of fully humanised antibodies devoid of T cell epitopes and with a consequent low risk of clinical immunogenicity.
In most cases, the complement system works for the brain's benefit, calling on microglia to clear unwanted debris or unneeded connections.
Scientists have known that the complement system takes a hit during dengue infection, but until now no one knew that it also plays a role in getting rid of dengue viruses.
The plasma CRP concentration increases following myocardial ischemia, and pharmacological evidence supports that CRP activates complement system and aggravates myocardial injury after ischemia-reperfusion in several species, including humans (15-18).
Although inhibition of the complement system is an absolute necessity for normal pregnancy, there is an increase in the concentrations of the anaphylatoxins C3a, C4a and C5a in the maternal circulation (1).
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