clinical trial

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Related to Controlled trials: Randomized clinical trial

clinical trial

[¦klin·i·kəl ′trīl]
(medicine)
A research study used to find better ways to treat individuals with a specific disease, patients are evaluated after being administered a new treatment or drug.
References in periodicals archive ?
Most controlled trials assessing youth with depression support the efficacy of cognitive-behavioral therapy (CBT).
Randomized controlled trial of sequential intravenous (i.
Evidence from a randomized, controlled trial demonstrated that when women were the primary contact, the effectiveness of patient-delivered partner therapy in preventing reinfection was comparable to and possibly greater than that of partner notification.
But in 1996, when new laparoscopic and balloon procedures were developed, scientists believed it was time to test these operations in a randomized, controlled trial.
Comment: Previous controlled trials have demonstrated a modest reduction in systolic blood pressure in hypertensive patients given supplemental vitamin C.
However, when the study authors evaluated the individual randomized controlled trials included in the meta-analyses, they found that more than 62% included information on the trial's funding source.
Results from the first eight randomized controlled trials led to a widespread position that routine electronic monitoring and intermittent auscultation are equivalent.
A third hypothetical study is not a randomized controlled trial but employs an observational methodology using "untreated" controls.
They analyzed results from six randomized, controlled trials involving a total of 967 patients that compared transmyocardial revascularization with maximal medical therapy In addition, they looked at studies that compared coronary artery bypass grafting (CABG) with CABG plus adjunctive transmyocardial revascularization, drawing on three randomized, controlled trials involving 327 patients and an additional three nonrandomized trials.
Even after taking these other factors into consideration and adjusting for possible selection bias, screening led to a nearly 50% reduction in breast cancer mortality, which is significantly higher than the 30% estimate that had been reported in previous randomized, controlled trials.
Such trials allow researchers to collect some information on a drug's efficacy from seriously ill patients who receive the treatment outside statistically controlled trials.
Point's Phase 3 NSCLC program consists of two randomized, double blind placebo controlled trials in up to 800 patients at approximately 100 sites in North America.

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