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circulation
(redirected from Coronary circulation)

   Also found in: Dictionary/thesaurus, Medical, Legal, Financial, Wikipedia, Hutchinson 0.01 sec.

circulation

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Human circulatory system. Oxygen-rich blood is shown in red, oxygen-poor blood in blue. The …
(credit: © Merriam-Webster Inc.)
Process by which nutrients, respiratory gases, and metabolic products are transported throughout the body. In humans, blood remains within a closed cardiovascular system composed of the heart, blood vessels, and blood. Arteries carry blood away from the heart under high pressure exerted by the heart's pumping action. Arteries divide into smaller arterioles, which branch into a network of tiny capillaries with thin walls across which gases and nutrients diffuse. Capillaries rejoin into larger venules, which unite to form veins, which carry blood back to the heart. (See artery; capillary; vein.) The right and left heart chambers send blood into separate pulmonary and systemic circulations. In the first, blood is carried from the heart to the lungs, where it picks up oxygen and releases carbon dioxide; in the second, blood is carried between the heart and the rest of the body, where it carries oxygen, nutrients, metabolic products, and wastes.


circulation
1. the transport of oxygenated blood through the arteries to the capillaries, where it nourishes the tissues, and the return of oxygen-depleted blood through the veins to the heart, where the cycle is renewed
2. the flow of sap through a plant
3. in circulation (of currency) serving as a medium of exchange

circulation [‚sər·kyə·′lā·shən]
(fluid mechanics)
The flow or motion of fluid in or through a given area or volume.
(mathematics)
For the circulation of a vector field around a closed path, the line integral of the field vector around the path.
(meteorology)
For an air mass, in the line integral of the tangential component of the velocity field about a closed curve.
(oceanography)
A water current flow occurring within a large area, usually in a closed circular pattern.
(physiology)
The movement of blood through defined channels and tissue spaces; movement is through a closed circuit in vertebrates and certain invertebrates.

Circulation

Those processes by which metabolic materials are transported from one region of an organism to another. Ultimately, the essential gases, nutrients, and waste products of metabolism are exchanged across cell membranes by diffusion. Diffusion is the movement of material, by random motion of molecules, from a region of high concentration to one of low concentration. The amount of material moved from one place to another depends on the difference in concentrations and on the distance between the two points. The greater the distance, the less movement of material per unit time for a given difference in concentration. Consequently, in all but the smallest animals, convection (or bulk circulation) of materials to the cell must be employed to supplement diffusion.

Protoplasmic movement aids diffusion at the intracellular level. In multicellular animals, however, either the external medium or extracellular body fluids, or both, are circulated. In sponges and coelenterates, water is pumped through definite body channels by muscular activity or, more often, by cilia or flagella on the cells lining the channels.

Coelenterates have a body wall derived from two cell layers; an outer ectoderm is separated from an inner endoderm by a noncellular gelatinous material (mesoglea). All higher animals have bodies consisting of three cell layers, with the ectoderm being separated from the endoderm by a cellular layer of mesoderm. The mesoderm proliferates and separates to develop a fluid-filled body cavity or coelom. The coelom separates the ectoderm (together with an outer layer of mesoderm) from the endoderm (which has an inner layer of mesoderm). Coelomic fluid is moved around by body movements or ciliary activity, but in larger animals this movement is usually inadequate to supply the metabolic requirements of the organs contained within the coelom. These needs are provided for by pumping a fluid, blood, to them through vessels, the blood vascular system. See Blood

When the blood is in a separate compartment from the rest of the extracellular fluid, the vascular system is described as closed. The two principal components of such systems are hearts and blood vessels. In such a system, the blood is circulated by a pump, the heart, through special channels, blood vessels; it comes into close association with the tissues only in the capillaries, fine vessels with walls only one cell thick. In some tissues or regions, larger blood spaces may exist, called sinuses. A closed vascular system is found in most annelids (segmented worms and leeches), cephalopod mollusks (squids and octopods), holothurian echinoderms (sea cucumbers), and vertebrates. See Blood vessels, Heart (vertebrate)

In vertebrates, a functional but anatomically closed connection exists between the extracellular spaces (between the cells) and the blood vascular system in the form of lymph channels. Lymph is derived from the noncellular component of blood (plasma), modified in its passage through the tissues, and is conducted to the veins by blind-ending lymphatic vessels, which are separate from blood vessels and coelomic space. See Lymphatic system

In most arthropods (crustaceans, insects), most mollusks (shellfish), and many ascidians (sea squirts), the extracellular spaces are confluent with the blood system. In these animals, blood is pumped through a limited network of vessels into a body cavity called a hemocoel. After bathing the tissues, blood (called hemolymph in these organisms) collects in sinuses and returns to the heart. This is the open vascular system. In animals with open circulatory systems, the coelom is much reduced.



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The device has proven to be safe and I am pleased with its ease-of-use and ability to provide both hemodynamic support and improved, sustained coronary circulation in the cath-lab.
These studies showed MSV60 increases coronary circulation, enhances heart muscle strength under hypoxic (low-oxygen) conditions, lowers oxygen consumption by the heart, offers free radical protection to heart tissue, and supports healthy blood platelets.
Currently, drug-eluting stents are the primary therapy for obstruction in the coronary circulation.
 
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